ArticleJournal of materials science. Materials in medicine2012
Biomimetic CaP coating incorporated with parathyroid hormone improves the osseointegration of titanium implant.
Article in Journal of materials science. Materials in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Efficacy of parathyroid hormone supplementation on the osseointegration of implants: a systematic review.Clinical oral investigations · 2016Pooled it
- Calcium phosphate ceramic as a model for enamel substitute material in dental applications.BDJ open · 2023Article
- Biocompatibility and osteointegration capability of β-TCP manufactured by stereolithography 3D printing:Open life sciences · 2023Article
- Velvet antler polypeptide combined with calcium phosphate coating to protect peripheral nerve cells from oxidative stress.Journal of molecular histology · 2022Article
- Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration.Pharmaceutics · 2022Review
- Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice.Frontiers in molecular biosciences · 2022Review
- Zoledronic acid and teriparatide have a complementary therapeutic effect on aseptic loosening in a rabbit model.BMC musculoskeletal disorders · 2021Article
- Biodegradable materials for bone defect repair.Military Medical Research · 2020Review
- Biomimetic Aspects of Restorative Dentistry Biomaterials.Biomimetics (Basel, Switzerland) · 2020Review
- Three-Dimensional Printed Porous Titanium Screw with Bioactive Surface Modification for Bone-Tendon Healing: A Rabbit Animal Model.International journal of molecular sciences · 2020Article
- Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds.Annals of translational medicine · 2019Article
- Single-dose local administration of parathyroid hormone (1-34, PTH) with β-tricalcium phosphate/collagen (β-TCP/COL) enhances bone defect healing in ovariectomized rats.Journal of bone and mineral metabolism · 2019Article
- Microstructure and Characteristics of Calcium Phosphate Layers on Bioactive Oxide Surfaces of Air-Sintered Titanium Foams after Immersion in Simulated Body Fluid.Materials (Basel, Switzerland) · 2016Article
- Intermittent Parathyroid Hormone Enhances Cancellous Osseointegration of a Novel Murine Tibial Implant.The Journal of bone and joint surgery. American volume · 2015Article
- How does the pathophysiological context influence delivery of bone growth factors?Advanced drug delivery reviews · 2015Review
- A review paper on biomimetic calcium phosphate coatings.The open biomedical engineering journal · 2015Article
- Local strategies to prevent and treat osteoporosis.Current osteoporosis reports · 2014Review
- Covalent Immobilization of Collagen on Titanium through Polydopamine Coating to Improve Cellular Performances of MC3T3-E1 Cells.RSC advances · 2013Article
- Cellular performance comparison of biomimetic calcium phosphate coating and alkaline-treated titanium surface.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parathyroid hormone (PTH) is a well-known therapeutic agent for osteoporosis treatment, however, the inconvenience of daily administration and side effect from systematic administration severely limits its application in clinic. PTH has been incorporated into a biomimetic calcium phosphate (CaP) coating via a co-precipitation method in a modified simulated body fluid. The aim of the current study is to evaluate the osseointegration response of PTH incorporated CaP coating on titanium implants. Implants with different doses of PTH were inserted into tibiae of mice and evaluated by X-ray, micro-CT, histology and back-scattered scanning electron microscopy. Improved osseointegration of the implants loaded with PTH was observed compared to CaP coating only after 28 days of implantation in mouse tibiae. Micro-CT analysis showed better bone integration around the implant incorporated with PTH. Bone area and bone contact evaluations have demonstrated that peri-implant bone regeneration is highly dependent on the dosage of PTH incorporated. The higher the PTH content, the more bone formed surrounding the implant. Therefore, our results suggest that biomimetic CaP coating could be a useful a carrier for PTH local delivery, which results in improved bone-to-implant integration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.