Evidence map›Paper›PMID 22638982›Full record

ReviewCurrent HIV/AIDS reports2012

Hepatitis C and HIV co-infection: new drugs in practice and in the pipeline.

Carrie L Jennings, Kenneth E Sherman

Abstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Effect of HIV on liver fibrosis among HCV-infected African Americans.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013
    Article
  7. HCV enters the twenty-first century.Current infectious disease reports · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Carrie L JenningsUniversity of Cincinnati College of Medicine/UCHealth, 231 Albert Sabin Way, Cincinnati, OH 45267-0595, USA.
Kenneth E Sherman

Funding

Mentorship in Liver DiseaseK24DK070528 · NIDDK · UNIVERSITY OF CINCINNATI · PI SHERMAN, KENNETH E · 2005 to 2014
$1.4M
NIDDK NIH HHS K24 DK070528
6 · The paper itself

Abstract

HCV/HIV coinfection continues to represent a serious health issue with risk of liver disease progression and development of hepatocellular carcinoma. Pegylated interferon with ribavirin is approved for treatment but results are suboptimal and tolerability poor. First-generation HCV protease inhibitors appear to significantly improve HCV treatment response in the setting of HIV infection. Interactions with HIV protease inhibitors have been documented, but the significance of this in terms of adverse reactions and HCV or HIV viral breakthrough remains uncertain. Next generation agents hold the promise of even better efficacy, with improved dosing schedules and perhaps decreased risk of drug:drug interactions.

Indexed as

CoinfectionAcquired Immunodeficiency SyndromeAnti-HIV AgentsAntiviral AgentsCD4 Lymphocyte CountDisease ProgressionDrug InteractionsDrug Therapy, CombinationFemaleHepacivirusHepatitis CHIV Protease InhibitorsHumansLiver FailureMaleProtease InhibitorsAnti-HIV AgentsAntiviral AgentsHIV Protease InhibitorsProtease InhibitorsRNA, Viral

Identifiers

PMID22638982
PMCPMC3551247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.