ArticleJournal of general internal medicine2012
Risk of unintentional overdose with non-prescription acetaminophen products.
Article in Journal of general internal medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 113 citations in OpenAlex.
- Effectiveness and sustainment of a tailored over-the-counter medication safety intervention in community pharmacies: A randomized controlled trial.Research in social & administrative pharmacy : RSAP · 2022Trial
- Electronic medication complete communication strategy for opioid prescriptions in the emergency department: Rationale and design for a three-arm provider randomized trial.Contemporary clinical trials · 2017Trial
- Take-Wait-Stop: a patient-centered strategy for writing PRN medication instructions.Journal of health communication · 2013Trial
- Self-Medication Safety Behaviours and Recognition of Pharmacological Risks: A Clinical Pharmacology Perspective.Cureus · 2026Article
- Automated Risk Assessment of Opioid Use: Analysis Using Pre-Trained Transformers on Social Media Data.JMIR infodemiology · 2026Article
- Personalized labeling: A strategy for supporting self-medicating patients' decision-making during selection and use.PloS one · 2026Article
- Paracetamol Dosing Errors in People Aged 12 Years and Over: An Analysis of Over 14,000 Cases Reported to an Australian Poisons Information Centre.Drug safety · 2024Article
- The Effects of Trade Names on the Misuse of Some Over-The-Counter Drugs and Assessment of Community Knowledge and Attitudes in Alkarak, Jordan.Patient preference and adherence · 2024Article
- Exploring Perceptions About Paracetamol, Tramadol, and Codeine on Twitter Using Machine Learning: Quantitative and Qualitative Observational Study.Journal of medical Internet research · 2023Observational
- Hepatoprotective Effects of Four Brazilian Savanna Species on Acetaminophen-Induced Hepatotoxicity in HepG2 Cells.Plants (Basel, Switzerland) · 2023Article
- Article
- Pattern and predictors of medication use among adults in southwestern Nigeria: A community-based cross-sectional study.Pharmacology research & perspectives · 2023Article
- The Three W's of Acetaminophen In Children: Who, Why, and Which Administration Mode.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Impact of acetaminophen product labelling changes in Canada on hospital admissions for accidental acetaminophen overdose: a population-based study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022Article
- Prevalences of and characteristics associated with single- and polydrug-involved U.S. Emergency Department Visits in 2018.Addictive behaviors · 2022Article
- Article
- A mixed-methods systematic review of the prevalence, reasons, associated harms and risk-reduction interventions of over-the-counter (OTC) medicines misuse, abuse and dependence in adults.Journal of pharmaceutical policy and practice · 2021Review
- Assessing Patient Perceptions and Experiences of Paracetamol in France: Infodemiology Study Using Social Media Data Mining.Journal of medical Internet research · 2021Article
- Impact of COVID-19 Lockdown Measures on Spanish People with Chronic Pain: An Online Study Survey.Journal of clinical medicine · 2020Article
- National Poison Center Calls Before vs After Availability of High-Dose Acetaminophen (Paracetamol) Tablets in Switzerland.JAMA network open · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere is increasing concern over the risk of consumer unintentional misuse of non-prescription (a.k.a. 'over-the-counter') medications containing acetaminophen, which could lead to acute liver failure.
objectiveTo determine the prevalence of potential misuse and overdose of over-the-counter medications containing acetaminophen, either alone or in combination.
designCross-sectional, structured interviews with literacy assessment.
settingOne academic and one community-based general internal medicine practice in Chicago, IL, and one academic general internal medicine practice and a public hospital clinic in Atlanta, GA. PATIENTS: Five hundred adults seeking primary care, ages 18-80. MEASUREMENT: Demonstration of how and when patients would take over-the-counter medications containing acetaminophen, alone or in combination with one another, over a 24-hour period.
resultsOverall, 23.8 % of participants demonstrated they would overdose on a single over-the-counter acetaminophen product by exceeding a dose of four grams in a 24-hour period; 5.2 % made serious errors by dosing out more than six grams. In addition, 45.6 % of adults demonstrated they would overdose by 'double-dipping' with two acetaminophen-containing products. In multivariable analyses, limited literacy (Relative Risk Ratio (RR) 1.65, 95 % Confidence Interval (CI) 1.03-2.66) and heavy acetaminophen use in the past six months (RR 1.70, 95 % CI 1.10-2.64) were independently associated with overdosing over-the-counter products.
conclusionMisunderstanding of the active ingredient and proper instructions for over-the-counter medications containing acetaminophen is common. The potential for errors and adverse events associated with unintentional misuse of these products is substantial, particularly among heavy users of acetaminophen and those with limited literacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.