ArticleNucleic acids research2012
iELM--a web server to explore short linear motif-mediated interactions.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Variant characterization in the intrinsically disordered human proteome.Nature structural & molecular biology · 2026Article
- Proteome-wide assessment of human interactome as a source of capturing domain-motif and domain-domain interactions.Journal of cell communication and signaling · 2024Article
- Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation.Molecular systems biology · 2024Article
- Mechnetor: a web server for exploring protein mechanism and the functional context of genetic variants.Nucleic acids research · 2021Article
- Article
- Resources to Discover and Use Short Linear Motifs in Viral Proteins.Trends in biotechnology · 2020Review
- Article
- Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins.Microbiome · 2017Article
- Exhaustive search of linear information encoding protein-peptide recognition.PLoS computational biology · 2017Article
- ELM 2016--data update and new functionality of the eukaryotic linear motif resource.Nucleic acids research · 2016Article
- Experimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for bad.Cell communication and signaling : CCS · 2015Review
- Identification of inhibitors of biological interactions involving intrinsically disordered proteins.International journal of molecular sciences · 2015Review
- Tissue-aware data integration approach for the inference of pathway interactions in metazoan organisms.Bioinformatics (Oxford, England) · 2015Article
- Drosophila Cyclin G and epigenetic maintenance of gene expression during development.Epigenetics & chromatin · 2015Article
- FunMod: a Cytoscape plugin for identifying functional modules in undirected protein-protein networks.Genomics, proteomics & bioinformatics · 2014Article
- The eukaryotic linear motif resource ELM: 10 years and counting.Nucleic acids research · 2014Article
- Article
- Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.The Journal of clinical investigation · 2013Article
- Alternative splicing tends to avoid partial removals of protein-protein interaction sites.BMC genomics · 2013Article
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Authors and funding
4 authors.
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Abstract
The recent expansion in our knowledge of protein-protein interactions (PPIs) has allowed the annotation and prediction of hundreds of thousands of interactions. However, the function of many of these interactions remains elusive. The interactions of Eukaryotic Linear Motif (iELM) web server provides a resource for predicting the function and positional interface for a subset of interactions mediated by short linear motifs (SLiMs). The iELM prediction algorithm is based on the annotated SLiM classes from the Eukaryotic Linear Motif (ELM) resource and allows users to explore both annotated and user-generated PPI networks for SLiM-mediated interactions. By incorporating the annotated information from the ELM resource, iELM provides functional details of PPIs. This can be used in proteomic analysis, for example, to infer whether an interaction promotes complex formation or degradation. Furthermore, details of the molecular interface of the SLiM-mediated interactions are also predicted. This information is displayed in a fully searchable table, as well as graphically with the modular architecture of the participating proteins extracted from the UniProt and Phospho.ELM resources. A network figure is also presented to aid the interpretation of results. The iELM server supports single protein queries as well as large-scale proteomic submissions and is freely available at http://i.elm.eu.org.
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