ArticleSurgery today2013
Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case.
Article in Surgery today, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Successful conversion therapy for presumed granulocyte colony-stimulating factor-producing hepatocellular carcinoma: a case report.Frontiers in oncology · 2026Article
- Tumor-derived G-CSF induces an immunosuppressive microenvironment in an osteosarcoma model, reducing response to CAR.GD2 T-cells.Journal of hematology & oncology · 2024Article
- Advances in Histological and Molecular Classification of Hepatocellular Carcinoma.Biomedicines · 2023Review
- Xuanhusuo powder has an anti-breast cancer effect by inhibiting myeloid-derived suppressor cell differentiation in the spleen of mice through down-regulating granulocyte colony stimulating factor.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Article
- State-of-the-art review on the correlations between pathological and magnetic resonance features of cirrhotic nodules.Histology and histopathology · 2022Review
- Review
- Imaging findings of granulocyte colony-stimulating factor-producing tumors: a case series and review of the literature.Japanese journal of radiology · 2021Review
- Review
- Pathologic and molecular features of hepatocellular carcinoma: An update.World journal of hepatology · 2021Review
- A case report of granulocyte colony-stimulating factor-producing hepatocellular carcinoma that recurred after long-term complete response.Clinical journal of gastroenterology · 2021Article
- Activation of stem cell up-regulation/mobilization: a cardiovascular risk in both mice and humans with implications for liver disease, psoriasis and SLE.Vascular health and risk management · 2019Review
- Hepatocellular carcinoma producing granulocyte colony-stimulating factor: diagnosis and treatment.International cancer conference journal · 2019Article
- A long-term survivor of undifferentiated carcinoma of the liver successfully treated with surgical treatments: A case report and literature review.International journal of surgery case reports · 2018Article
- Granulocyte colony-stimulating factor-producing hepatocellular carcinoma with abrupt changes.World journal of clinical oncology · 2016Review
- Hypersplenism in liver disease and SLE revisited: current evidence supports an active rather than passive process.BMC hematology · 2016Article
- Expression of CD163 prevents apoptosis through the production of granulocyte colony-stimulating factor in meningioma.Neuro-oncology · 2013Article
- Granulocyte Colony-stimulating Factor Producing Oropharyngeal Squamous Cell Carcinoma.In vivo (Athens, Greece)Article
- Granulocyte Colony-Stimulating Factor Use in Decompensated Cirrhosis: Lack of Survival Benefit.Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This report describes a rare case of hepatocellular carcinoma (HCC) producing granulocyte colony-stimulating factor (G-CSF). A 46-year-old male with chronic hepatitis B, who presented with fever, general malaise, loss of appetite, and weight loss, had a huge liver mass in the portal region. He had marked granulocytosis and his serum level of G-CSF was elevated. Complete tumor resection was performed, and the pathological assessment of the resected specimen revealed HCC with extensive sarcomatous changes and immunohistochemical staining for G-CSF and G-CSF receptor. Only a few cases of G-CSF-producing HCC have been reported, and this is the first case of G-CSF-producing HCC that also expressed G-CSF receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.