Trial reportArchives of general psychiatry2012
Alterations in neural processing and psychopathology in children raised in institutions.
Trial report in Archives of general psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- The mind, brain, and body study: A protocol for examining the effects of the gut-brain-immune axis on internalizing symptoms in youth exposed to caregiving-related early adversity.Brain, behavior, & immunity - health · 2024Article
- Early life adversity in primates: Behavioral, endocrine, and neural effects.Psychoneuroendocrinology · 2024Article
- Perinatal and early childhood biomarkers of psychosocial stress and adverse experiences.Pediatric research · 2022Review
- Cognitive Stimulation as a Mechanism Linking Socioeconomic Status With Executive Function: A Longitudinal Investigation.Child development · 2020Observational
- Living in a Disadvantaged Neighborhood Affects Neural Processing of Facial Trustworthiness.Frontiers in psychology · 2020Article
- Distinct aspects of the early environment contribute to associative memory, cued attention, and memory-guided attention: Implications for academic achievement.Developmental cognitive neuroscience · 2019Article
- The role of the visual association cortex in scaffolding prefrontal cortex development: A novel mechanism linking socioeconomic status and executive function.Developmental cognitive neuroscience · 2019Review
- Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults: Trajectories of Frontal Theta Oscillations During a Go/No-Go Task.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Effects of methylphenidate on the ERP amplitude in youth with ADHD: A double-blind placebo-controlled cross-over EEG study.PloS one · 2019Article
- Adolescents with Persistent History of Maltreatment Fail in Antisaccadic Task.Journal of child & adolescent trauma · 2018Article
- Prenatal maternal mood patterns predict child temperament and adolescent mental health.Journal of affective disorders · 2018Article
- Early experience and brain development.Wiley interdisciplinary reviews. Cognitive science · 2017Review
- Discrimination of amygdala response predicts future separation anxiety in youth with early deprivation.Journal of child psychology and psychiatry, and allied disciplines · 2016Article
- Disruptions of working memory and inhibition mediate the association between exposure to institutionalization and symptoms of attention deficit hyperactivity disorder.Psychological medicine · 2016Article
- Reduced Working Memory Mediates the Link between Early Institutional Rearing and Symptoms of ADHD at 12 Years.Frontiers in psychology · 2016Article
- Future Directions in Childhood Adversity and Youth Psychopathology.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2016Article
- Early Adverse Experiences and the Developing Brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Deviations from the expectable environment in early childhood and emerging psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Relation of Childhood Home Environment to Cortical Thickness in Late Adolescence: Specificity of Experience and Timing.PloS one · 2015Article
- Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene.Frontiers in behavioral neuroscience · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
contextYoung children raised in institutional settings experience severe deprivation in social, emotional, and cognitive stimulation. Although this deprivation is likely to disrupt brain development in ways that increase the risk for psychopathology, neurodevelopmental mechanisms linking adverse early environments to psychopathology remain poorly understood.
objectiveTo examine whether abnormalities in the neural processing of facial and emotional stimuli are related to the high rates of psychopathology observed among institutionally reared children. DESIGN, SETTING, AND
participantsData were drawn from the Bucharest Early Intervention Project, a cohort of children raised in institutions in Romania and an age-matched sample of community control subjects. At entry to the study (mean age, 22 months), event-related potentials were used to measure neural processing in 2 tasks: familiar and unfamiliar faces (n=114) and facial displays of emotion (n=74).
main outcome measuresPsychiatric symptoms were assessed using the Preschool Age Psychiatric Assessment among children aged 54 months.
resultsAs previously reported, institutionally reared children had elevated symptoms of attention-deficit/hyperactivity disorder (ADHD), anxiety, depression, and disruptive behavior compared with control children, and peak amplitudes of the P100 and P700 in response to facial stimuli were blunted among institutionalized children compared with community children in both tasks. Current analyses reveal that children with reduced P100 and P700 amplitudes in response to facial stimuli exhibited higher levels of ADHD and anxiety symptoms. Peak amplitude of the P700 in response to facial stimuli significantly mediated the association between institutional rearing and ADHD symptoms at 54 months.
conclusionExposure to institutional rearing disrupts the P700, conferring risk for the onset of psychopathology. The high levels of ADHD symptoms among children exposed to early life deprivation may be attributable, in part, to abnormal patterns of neurodevelopment generated by these adverse rearing environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.