ArticleNature structural & molecular biology2012
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding.
Article in Nature structural & molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 106 citations in OpenAlex.
- Segmented poly(A) tails with microRNA target sites confer tissue-specific regulation for mRNA therapeutics.Molecular therapy. Nucleic acids · 2026Article
- Regulation by the RNA-binding protein Unkempt at its effector interface.Nature communications · 2024Article
- LncRNA PRBC induces autophagy to promote breast cancer progression through modulating PABPC1-mediated mRNA stabilization.Oncogene · 2024Article
- Review
- The molecular basis of coupling between poly(A)-tail length and translational efficiency.eLife · 2021Article
- Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases.International journal of molecular sciences · 2021Review
- The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization.Non-coding RNA · 2021Review
- Extracellular MicroRNAs as Intercellular Mediators and Noninvasive Biomarkers of Cancer.Cancers · 2020Review
- The Role of Dynamic miRISC During Neuronal Development.Frontiers in molecular biosciences · 2020Review
- AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals.Frontiers in bioscience (Landmark edition) · 2020Review
- Mechanistic Insights into MicroRNA-Mediated Gene Silencing.Cold Spring Harbor perspectives in biology · 2019Review
- Temporospatial guidance of activity-dependent gene expression by microRNA: mechanisms and functional implications for neural plasticity.Nucleic acids research · 2019Review
- Ciphers and Executioners: How 3'-Untranslated Regions Determine the Fate of Messenger RNAs.Frontiers in genetics · 2019Review
- Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics.Nature genetics · 2018Article
- MicroRNAs from plants to animals, do they define a new messenger for communication?Nutrition & metabolism · 2018Review
- Intracytoplasmic Re-localization of miRISC Complexes.Frontiers in genetics · 2018Review
- The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency.PloS one · 2018Article
- The 3' end of the story: deciphering combinatorial interactions that control mRNA fate.Genome biology · 2017Article
- The influence of microRNAs and poly(A) tail length on endogenous mRNA-protein complexes.Genome biology · 2017Article
- In vitro labeling strategies for in cellulo fluorescence microscopy of single ribonucleoprotein machines.Protein science : a publication of the Protein Society · 2017Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyadenylated mRNAs are typically more strongly repressed by microRNAs (miRNAs) than their nonadenylated counterparts. Using a Drosophila melanogaster cell-free translation system, we found that this effect is mediated by the poly(A)-binding protein (PABP). miRNA repression was positively correlated with poly(A) tail length, but this stimulatory effect on repression was lost when translation was repressed by the tethered GW182 silencing domain rather than the miRNA-induced silencing complex (miRISC) itself. These findings are mechanistically explained by a notable function of PABP: it promotes association of miRISC with miRNA-regulated mRNAs. We also found that PABP association with mRNA rapidly diminished with miRISC recruitment and before detectable deadenylation. We integrated these data into a revised model for the function of PABP and the poly(A) tail in miRNA-mediated translational repression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.