ArticlePlant physiology2012
Systems dynamic modeling of the stomatal guard cell predicts emergent behaviors in transport, signaling, and volume control.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed, 174 citations in OpenAlex.
- Engineering principles in plant metabolism: integrating control, mechanics, and transport under dynamic environments.Plant physiology · 2026Review
- Cell wall water shields stomata against falling leaf airspace humidity.The New phytologist · 2026Article
- A guard cell carbonic anhydrase binds and regulates SLAC1 separate from its catalytic activity.Nature communications · 2026Article
- Modelling stomatal mechanics: a critical review.The New phytologist · 2026Review
- Guard cell starch and malate metabolism facilitate stomatal opening in response to low COThe New phytologist · 2026Article
- Multi-physics modeling for ion homeostasis in multi-compartment plant cells using an energy function.PLoS computational biology · 2025Article
- Guard cells on the adaxial and abaxial leaf surfaces use different compositions of potassium ion channels to drive light-induced stomatal opening.Nature plants · 2025Article
- Guard cell-specific glycine decarboxylase manipulation affects Arabidopsis photosynthesis, growth and stomatal behavior.The New phytologist · 2025Article
- Analysis of Electrome as a Tool for Plant Monitoring: Progress and Perspectives.Plants (Basel, Switzerland) · 2025Review
- Chlorine Modulates Photosynthetic Efficiency, Chlorophyll Fluorescence in Tomato Leaves, and Carbohydrate Allocation in Developing Fruits.International journal of molecular sciences · 2025Article
- A C4 plant K+ channel accelerates stomata to enhance C3 photosynthesis and water use efficiency.Plant physiology · 2025Article
- Article
- Metabolic modeling reveals distinct roles of sugars and carboxylic acids in stomatal opening as well as unexpected carbon fluxes.The Plant cell · 2024Article
- Dual function of overexpressing plasma membrane HScience advances · 2024Article
- Prolonged Post-Harvest Preservation in Lettuce (Plants (Basel, Switzerland) · 2024Article
- A charged existence: A century of transmembrane ion transport in plants.Plant physiology · 2024Review
- OnGuard3e: A predictive, ecophysiology-ready tool for gas exchange and photosynthesis research.Plant, cell & environment · 2023Article
- The Growth Oscillator and Plant Stomata: An Open and Shut Case.Plants (Basel, Switzerland) · 2023Review
- Molecular response and evolution of plant anion transport systems to abiotic stress.Plant molecular biology · 2022Review
- Engineering a KNature plants · 2022Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The dynamics of stomatal movements and their consequences for photosynthesis and transpirational water loss have long been incorporated into mathematical models, but none have been developed from the bottom up that are widely applicable in predicting stomatal behavior at a cellular level. We previously established a systems dynamic model incorporating explicitly the wealth of biophysical and kinetic knowledge available for guard cell transport, signaling, and homeostasis. Here we describe the behavior of the model in response to experimentally documented changes in primary pump activities and malate (Mal) synthesis imposed over a diurnal cycle. We show that the model successfully recapitulates the cyclic variations in H⁺, K⁺, Cl⁻, and Mal concentrations in the cytosol and vacuole known for guard cells. It also yields a number of unexpected and counterintuitive outputs. Among these, we report a diurnal elevation in cytosolic-free Ca²⁺ concentration and an exchange of vacuolar Cl⁻ with Mal, both of which find substantiation in the literature but had previously been suggested to require additional and complex levels of regulation. These findings highlight the true predictive power of the OnGuard model in providing a framework for systems analysis of stomatal guard cells, and they demonstrate the utility of the OnGuard software and HoTSig library in exploring fundamental problems in cellular physiology and homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.