ArticleNature materials2012
Plasmonic nanosensors with inverse sensitivity by means of enzyme-guided crystal growth.
Article in Nature materials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 81 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed.
- Geometry-Controlled Assembly of Self-Standing Nanorods With Undisturbed Plasmonics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Synthesis and Optimization of Highly Bright Silver-Coated Au Nanostars with Tunable Plasmonic Properties.ACS nanoscience Au · 2025Article
- Nanomaterial-Enhanced Biosensing: Mechanisms and Emerging Applications.Advanced healthcare materials · 2025Review
- Facile Immunoassay Constructed by Gold Nanostar-Labeled Rabbit-AFP Antibody and Gold Nanoparticle-Conjugated Goat Anti-Rabbit IgG.Nanomaterials (Basel, Switzerland) · 2025Article
- Multiscale Thermal Analysis of Gold Nanostars in 3D Tumor Spheroids: Integrating Cellular-Level Photothermal Effects and Nanothermometry via X-Ray Spectroscopy.Advanced healthcare materials · 2025Article
- Innovative Applications of Nanopore Technology in Tumor Screening: An Exosome-Centric Approach.Biosensors · 2025Review
- An Acoustofluidic Picoinjector.Sensors and actuators. B, Chemical · 2024Article
- Magnetic augmentation through multi-gradient coupling enables direct and programmable profiling of circulating biomarkers.Nature communications · 2024Article
- Quantitative Galactose Colorimetric Competitive Assay Based on Galactose Dehydrogenase and Plasmonic Gold Nanostars.Biosensors · 2023Article
- Feasibility of NAD(P)/NAD(P)H as redox agents in enzymatic plasmonic gold nanostar assays for galactose quantification.Royal Society open science · 2023Article
- Full Control of Plasmonic Nanocavities Using Gold Decahedra-on-Mirror Constructs with Monodisperse Facets.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Monocrystalline Labeling Enables Stable Plasmonic Enhancement for Isolation-Free Extracellular Vesicle Analysis.Small (Weinheim an der Bergstrasse, Germany) · 2023Article
- Review
- Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors.Mikrochimica acta · 2022Review
- Ultrasensitive Detection of Biomarkers in a Color-Switchable Microcavity-Reactor Laser.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- The Effect of Capping Agents on Gold Nanostar Stability, Functionalization, and Colorimetric Biosensing Capability.Nanomaterials (Basel, Switzerland) · 2022Article
- Noble Metal Nanoparticle Biosensors: From Fundamental Studies toward Point-of-Care Diagnostics.Accounts of chemical research · 2022Review
- Influence of Random Plasmonic Metasurfaces on Fluorescence Enhancement.Materials (Basel, Switzerland) · 2022Article
- Oscillating the local milieu of polymersome interiors via single input-regulated bilayer crosslinking and permeability tuning.Nature communications · 2022Article
- Flower-Like Colloidal Particles through Precipitation Polymerization of Redox-Responsive Liquid Crystals.Angewandte Chemie (International ed. in English) · 2021Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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- Erratum issued
- Erratum issued
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lowering the limit of detection is key to the design of sensors needed for food safety regulations, environmental policies and the diagnosis of severe diseases. However, because conventional transducers generate a signal that is directly proportional to the concentration of the target molecule, ultralow concentrations of the molecule result in variations in the physical properties of the sensor that are tiny, and therefore difficult to detect with confidence. Here we present a signal-generation mechanism that redefines the limit of detection of nanoparticle sensors by inducing a signal that is larger when the target molecule is less concentrated. The key step to achieve this inverse sensitivity is to use an enzyme that controls the rate of nucleation of silver nanocrystals on plasmonic transducers. We demonstrate the outstanding sensitivity and robustness of this approach by detecting the cancer biomarker prostate-specific antigen down to 10(-18) g ml(-1) (4 × 10(-20) M) in whole serum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.