ArticlePhysiology & behavior2012
Paternal responsiveness is associated with, but not mediated by reduced neophobia in male California mice (Peromyscus californicus).
Article in Physiology & behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Sex-Specific Effects of Experience With Pups on Perineuronal Net Expression in the Biparental California Mouse (Peromyscus californicus).The Journal of comparative neurology · 2025Article
- Involvement of Serotonergic Projections from the Dorsal Raphe to the Medial Preoptic Area in the Regulation of the Pup-Directed Paternal Response of Male Mandarin Voles.International journal of molecular sciences · 2023Article
- Article
- Acute inhibition of dopamine β-hydroxylase attenuates behavioral responses to pups in adult virgin California mice (Peromyscus californicus).Hormones and behavior · 2022Article
- Translational relevance of behavioral, neural, and electroencephalographic profiles in a mouse model of post-traumatic stress disorder.Neurobiology of stress · 2021Article
- Plasticity of the paternal brain: Effects of fatherhood on neural structure and function.Developmental psychobiology · 2021Review
- Different behavioral, neural and neuropeptide responses of fathers to their own and to alien pups in mandarin voles.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Enduring Effects of Paternal Deprivation in California Mice (Frontiers in behavioral neuroscience · 2018Article
- Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation.Integrative and comparative biology · 2017Review
- Metabolic and affective consequences of fatherhood in male California mice.Physiology & behavior · 2017Article
- Effects of repeated pup exposure on behavioral, neural, and adrenocortical responses to pups in male California mice (Peromyscus californicus).Hormones and behavior · 2017Article
- Fatherhood contributes to increased hippocampal spine density and anxiety regulation in California mice.Brain and behavior · 2016Article
- Functional significance of hormonal changes in mammalian fathers.Journal of neuroendocrinology · 2014Review
- Differences in placentophagia in relation to reproductive status in the California mouse (Peromyscus californicus).Developmental psychobiology · 2014Article
- Autonomic, behavioral and neuroendocrine correlates of paternal behavior in male prairie voles.Physiology & behavior · 2014Article
- Chronic variable stress in fathers alters paternal and social behavior but not pup development in the biparental California mouse (Peromyscus californicus).Hormones and behavior · 2013Article
- Physiological and neuroendocrine responses to chronic variable stress in male California mice (Peromyscus californicus): Influence of social environment and paternal state.Psychoneuroendocrinology · 2013Article
- Effect of reproductive status on hypothalamic-pituitary-adrenal (HPA) activity and reactivity in male California mice (Peromyscus californicus).Physiology & behavior · 2013Article
- The CRF system and social behavior: a review.Frontiers in neuroscience · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Hormones associated with pregnancy and parturition have been implicated in facilitating the onset of maternal behavior via reductions in neophobia, anxiety, and stress responsiveness. To determine whether the onset of paternal behavior has similar associations in biparental male California mice (Peromyscus californicus), we compared paternal responsiveness, neophobia (novel-object test), and anxiety-like behavior (elevated plus maze, EPM) in isolated virgins (housed alone), paired virgins (housed with another male), expectant fathers (housed with pregnant pairmate), and new fathers (housed with pairmate and pups). Corticotropin-releasing hormone (CRH) and Fos immunoreactivity (IR) were quantified in brain tissues following exposure to a predator-odor stressor or under baseline conditions. New fathers showed lower anxiety-like behavior than expectant fathers and isolated virgins in EPM tests. In all housing conditions, stress elevated Fos-IR in the hypothalamic paraventricular nucleus (PVN). Social isolation reduced overall (baseline and stress-induced) Fos- and colocalized Fos/CRH-IR, and increased overall CRH-IR, in the PVN. In the central nucleus of the amygdala, social isolation increased stress-induced CRH-IR and decreased stress-induced activation of CRH neurons. Across all housing conditions, paternally behaving males displayed more anxiety-related behavior than nonpaternal males in the EPM, but showed no differences in CRH- or Fos-IR. Finally, the latency to engage in paternal behavior was positively correlated with the latency to approach a novel object. These results suggest that being a new father does not reduce anxiety, neophobia, or neural stress responsiveness. Low levels of neophobia, however, were associated with, but not necessary for paternal responsiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.