ArticleFungal genetics and biology : FG & B2012
Candida albicans infection inhibits macrophage cell division and proliferation.
Article in Fungal genetics and biology : FG & B, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen Candida glabrata.FEMS yeast research · 2024Article
- Extracellular Vesicles fromJournal of fungi (Basel, Switzerland) · 2023Article
- "Amyloid-beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease.Aging cell · 2020Review
- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
- Review
- Modelling the host-pathogen interactions of macrophages andJournal of the Royal Society, Interface · 2017Article
- Interactions of fungal pathogens with phagocytes.Nature reviews. Microbiology · 2016Review
- Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison.Frontiers in cellular and infection microbiology · 2016Review
- Novel insights into host-fungal pathogen interactions derived from live-cell imaging.Seminars in immunopathology · 2015Review
- Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment.Mycopathologia · 2014Review
- Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis virulence in the non-conventional host Galleria mellonella.Virulence · 2014Article
- Hyphal growth of phagocytosed Fusarium oxysporum causes cell lysis and death of murine macrophages.PloS one · 2014Article
- Kinetic studies of Candida parapsilosis phagocytosis by macrophages and detection of intracellular survival mechanisms.Frontiers in microbiology · 2014Article
- Article
- Live-cell video microscopy of fungal pathogen phagocytosis.Journal of visualized experiments : JoVE · 2013Article
- Evaluation of the relationship between fungal infection, neutrophil leukocytes and macrophages in cervicovaginal smears: Light microscopic examination.Journal of cytologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The pathogenicity of the opportunistic human fungal pathogen Candida albicans depends on its ability to inhibit effective destruction by host phagocytes. Using live cell video microscopy, we show here for the first time that C. albicans inhibits cell division in macrophages undergoing mitosis. Inhibition of macrophage cell division is dependent on the ability of C. albicans to form hyphae, as it is rarely observed following phagocytosis of UV-killed or morphogenesis-defective mutant Candida. Interestingly, failed cell division following phagocytosis of hyphal C. albicans is surprisingly common, and leads to the formation of large multinuclear macrophages. This raises question as to whether inhibition of macrophage cell division is another virulence attribute of C. albicans or enables host macrophages to contain the pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.