Evidence map›Paper›PMID 22633998›Full record

ReviewTrends in molecular medicine2012

Environmental enteropathy: critical implications of a poorly understood condition.

Poonum S Korpe, William A Petri

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in molecular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06397924 (Edible Insects), which is not on this map. Cited by 262 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
262citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06397924 nacompletednot on this mapstarted 2023, after this paper: background citation

Edible Insects: Good for the Gut and the Globe

TypeinterventionalSponsorColorado State UniversityRan2023 to 2024Enrolled18ConditionsIrritable Bowel SyndromeArmsChitin Fiber, Placebo
3 · Its place in the literature

Who cites it

262 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Interventions to improve sanitation for preventing diarrhoea.The Cochrane database of systematic reviews · 2023
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202 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Poonum S KorpeDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908-1337, USA.
William A Petri

Funding

FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
Global Biothreats Training ProgramT32AI055432 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CRISS, ALISON K, PETRI, WILLIAM A · 2003 to 2022
$4.0M
NIAID NIH HHS R01 AI043596NIAID NIH HHS T32 AI055432
6 · The paper itself

Abstract

Environmental enteropathy (also called tropical enteropathy) is a subclinical condition caused by constant fecal-oral contamination and resulting in blunting of intestinal villi and intestinal inflammation. Although these histological changes were discovered decades ago, the clinical impact of environmental enteropathy is just starting to be recognized. The failure of nutritional interventions and oral vaccines in the developing world may be attributed to environmental enteropathy, as the intestinal absorptive and immunologic functions are significantly deranged. Here we review the existing literature and examine potential mechanisms of pathogenesis for this poorly understood condition.

Indexed as

EnvironmentAnimalsBiomarkersDiagnosis, DifferentialHumansIntestinal DiseasesMalabsorption SyndromesT-LymphocytesBiomarkers

Identifiers

PMID22633998
PMCPMC3372657

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.