ArticleBiochimica et biophysica acta2012
Inhibitory role of adiponectin peptide I on rat choroidal neovascularization.
Article in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- Emerging Role of Adiponectin/AdipoRs Signaling in Choroidal Neovascularization, Age-Related Macular Degeneration, and Diabetic Retinopathy.Biomolecules · 2023Review
- Article
- Role of Adiponectin Peptide I (APNp1) in Age-Related Macular Degeneration.Biomolecules · 2022Article
- Review
- Targeting Neurovascular Interaction in Retinal Disorders.International journal of molecular sciences · 2020Review
- FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice.Cell reports · 2017Article
- Intravitreal itraconazole inhibits laser-induced choroidal neovascularization in rats.PloS one · 2017Article
- A mutation in ADIPOR1 causes nonsyndromic autosomal dominant retinitis pigmentosa.Human genetics · 2016Article
- Review: adiponectin in retinopathy.Biochimica et biophysica acta · 2016Review
- Role of adiponectin in metabolic and cardiovascular disease.Journal of exercise rehabilitation · 2014Review
- Expression of adiponectin and its receptors in type 1 diabetes mellitus in human and mouse retinas.Molecular vision · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Age-related macular degeneration (AMD) is a leading cause of central blindness in the elderly population. The wet type of AMD is characterized by extensive growth of new vessels. One of the effective strategies to treat wet AMD is to limit the choroidal neovascularization (CNV). We studied the effects of adiponectin peptide I (APNpI) on new vessel growth in laser-induced rat model of wet AMD and on rat choroidal endothelial cell (CEC) culture. CNV size and vessel density were investigated by microscopy. Immunohistochemical staining (IHC) for von Willebrand Factor (vWF), APN, APN receptors 1 (AdipoR1), 2 (AdipoR2), VEGF, VEGF receptor 2 (VEGF-R2), proliferating cell nuclear antigen (PCNA) was performed in CNV area. The mRNA expression of VEGF and VEGF-R2 in RPE-choroid was investigated by RT-PCR and real-time PCR. APNpI inhibited area of CNV by 4 fold, number of vWF positive vessels by 99% and area of subretinal tissue by 40%. The expression of VEGF and VEGF-R2 at mRNA and protein levels decreased after APNpI treatment in vivo. Proliferative index (PCNA) was 5 folds less in laser spots of APNpI treated rats compared to controls. In conclusion, APNpI inhibited formation of new vessels in rat model of CNV by decreasing VEGF, VEGF-R2 expression and cell proliferation. Thus, APNpI may have potential therapeutic use for AMD treatment since it significantly inhibited CNV.
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Registered trials
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