ArticlePhysics of life reviews2012
The quadratic hazard model for analyzing longitudinal data on aging, health, and the life span.
Article in Physics of life reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- Erythrocyte Count, Anemia, and the Human Natural Lifespan Limit: Evidence from the Long Life Family Study.bioRxiv : the preprint server for biology · 2026Article
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- Cerebrolysin, hemorrhagic transformation, and anticoagulation timing after reperfusion therapy in stroke:Frontiers in pharmacology · 2025Article
- Forecasting prevalence and mortality of Alzheimer's disease using the partitioning models.Experimental gerontology · 2023Article
- Understanding Alzheimer's disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study.Mechanisms of ageing and development · 2023Article
- Allostatic load in the context of disasters.Psychoneuroendocrinology · 2022Review
- Interpretable machine learning for high-dimensional trajectories of aging health.PLoS computational biology · 2022Article
- Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.Mechanisms of ageing and development · 2021Article
- Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity.Mechanisms of ageing and development · 2021Review
- Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans.Journal of translational genetics and genomics · 2021Article
- Physiological Dysregulation, Frailty, and Impacts on Adverse Health and Functional Outcomes.Frontiers in medicine · 2021Article
- Application of Traditional and Emerging Methods for the Joint Analysis of Repeated Measurements With Time-to-Event Outcomes in Rheumatology.Arthritis care & research · 2020Review
- Genetics of physiological dysregulation: findings from the long life family study using joint models.Aging · 2020Article
- "Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- stpm: an R package for stochastic process model.BMC bioinformatics · 2017Article
- A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice.Scientific reports · 2017Article
- Insights into mortality patterns and causes of death through a process point of view model.Biogerontology · 2017Review
- Dynamics of biomarkers in relation to aging and mortality.Mechanisms of ageing and development · 2016Review
- How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.Biogerontology · 2016Review
- Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk.Frontiers in public health · 2016Article
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7 authors.
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Abstract
A better understanding of processes and mechanisms linking human aging with changes in health status and survival requires methods capable of analyzing new data that take into account knowledge about these processes accumulated in the field. In this paper, we describe an approach to analyses of longitudinal data based on the use of stochastic process models of human aging, health, and longevity which allows for incorporating state of the art advances in aging research into the model structure. In particular, the model incorporates the notions of resistance to stresses, adaptive capacity, and "optimal" (normal) physiological states. To capture the effects of exposure to persistent external disturbances, the notions of allostatic adaptation and allostatic load are introduced. These notions facilitate the description and explanation of deviations of individuals' physiological indices from their normal states, which increase the chances of disease development and death. The model provides a convenient conceptual framework for comprehensive systemic analyses of aging-related changes in humans using longitudinal data and linking these changes with genotyping profiles, morbidity, and mortality risks. The model is used for developing new statistical methods for analyzing longitudinal data on aging, health, and longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.