ArticleInternational journal of cardiology2013
Worsening renal function is not associated with response to treatment in acute heart failure.
Article in International journal of cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.Circulation · 2018Trial
- Effectiveness and safety of combining thiazides with loop diuretics vs. loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study.British journal of clinical pharmacology · 2026Article
- Kidneys Under Pressure: The Consequence of Heart Failure and Elevated Filling Pressures.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Article
- Renal function modifies the association between hemoconcentration and outcomes in hospitalized heart failure patients.Internal and emergency medicine · 2024Article
- Telmisartan versus EnalapRil In heart failure with redUced ejection fraction patients with Moderately impaired kidney Functions; randomized controlled trial: "TRIUMF trial".The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023Article
- Predictive value of blood urea nitrogen in heart failure: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Systematic Review of the Association Between Worsening Renal Function and Mortality in Patients With Acute Decompensated Heart Failure.Kidney international reports · 2020Article
- The role of the kidney in acute and chronic heart failure.Heart failure reviews · 2020Review
- The top tertile of hematocrit change during hospitalization is associated with lower risk of mortality in acute heart failure patients.BMC cardiovascular disorders · 2017Observational
- Different trajectories and significance of B-type natriuretic peptide, congestion and acute kidney injury in patients with heart failure.Internal and emergency medicine · 2017Article
- Loop diuretics in acute heart failure: beyond the decongestive relief for the kidney.Critical care (London, England) · 2015Article
- Cardiorenal Syndrome Type 1: Renal Dysfunction in Acute Decompensated Heart Failure.Journal of clinical outcomes management : JCOM · 2015Article
- Intravenous furosemide in decompensated heart failure: do not protocolize dosing but the desired effect!Critical care (London, England) · 2014Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundAbout a fourth of acute decompensated heart failure (ADHF) patients develop renal dysfunction during their admission. To date, the association of ADHF treatment with the development of worsening renal function (WRF) remains contentious. Thus, we examined the association of WRF with changes in BNP levels and with mortality.
methodsWe performed retrospective chart review of patients admitted with ADHF who had BNP, eGFR, creatinine and blood urea nitrogen (BUN) values measured both on admission and discharge. Survival analysis was conducted using Cox proportional hazards model and correlation was measured using Spearman's rank correlation test.
results358 patients admitted for ADHF were evaluated. WRF was defined as >20% reduction in eGFR from admission to discharge and response to treatment was assessed by ΔBNP. There was a statistically significant reduction in BNP and increase in BUN during the admission. ΔBNP did not correlate with either ΔGFR or ΔBUN. Patients who developed WRF and those who did not, had a similar reduction in BNP. On univariate survival analysis, ΔBUN, but not ΔeGFR, was associated with 1-year mortality. In multivariate Cox proportional hazards model, BUN at discharge was associated with 1-year mortality (HR: 1.02, p<0.001), but ΔeGFR and ΔBUN were not associated with the primary endpoint.
conclusionDuring ADHF treatment, ΔBNP was not associated with changes in renal function. Development of WRF during ADHF treatment was not associated with mortality. Our study suggests that development of WRF should not preclude diuresis in ADHF patients in the absence of volume depletion.
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