Evidence map›Paper›PMID 22633075›Full record

ReviewTrends in microbiology2012

Viral and host control of cytomegalovirus maturation.

Ritesh Tandon, Edward S Mocarski

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed.

  1. A comprehensive method for quantifying human cytomegalovirus plaque assays.Frontiers in cellular and infection microbiology · 2026
    Article
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  6. Review
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  10. Host Cell Signatures of the Envelopment Site within Beta-Herpes Virions.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Article
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  20. STING facilitates nuclear import of herpesvirus genome during infection.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ritesh TandonDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. rtandon@emory.edu
Edward S Mocarski

Funding

CYTOMEGALOVIRUS DNA REPLICATION AND RECOMBINATIONR01AI020211 · NIAID · STANFORD UNIVERSITY · PI EDWARD S MOCARSKI, EDWARD S. · 1985 to 2021
$5.9M
CYTOMEGALOVIRUS PATHOGENESIS IN IMMUNODEFICIENCYR01AI030363 · NIAID · STANFORD UNIVERSITY · PI EDWARD S MOCARSKI, EDWARD S. · 1991 to 2011
$2.7M
Immune modulation in cytomegalovirus infectionR56AI030363 · NIAID · EMORY UNIVERSITY · PI EDWARD S MOCARSKI, EDWARD S. · 2012 to 2012
$388k
Cytomegalovirus Pathogenesis in ImmunodeficiencyR21AI030363 · NIAID · STANFORD UNIVERSITY · PI MOCARSKI, EDWARD S. · 2001 to 2001
$277k
NIAID NIH HHS R01 AI020211NIAID NIH HHS R01 AI030363NIAID NIH HHS R21 AI030363NIAID NIH HHS R56 AI030363
6 · The paper itself

Abstract

Maturation in herpesviruses initiates in the nucleus of the infected cell, with encapsidation of viral DNA to form nucleocapsids, and concludes with envelopment in the cytoplasm to form infectious virions that egress the cell. The entire process of virus maturation is orchestrated by protein-protein interactions and enzymatic activities of viral and host origin. Viral tegument proteins play important roles in maintaining the structural stability of capsids and directing the acquisition of virus envelope. Envelopment occurs at modified host membranes and exploits host vesicular trafficking. In this review, we summarize current knowledge of and concepts in human cytomegalovirus (HCMV) maturation and their parallels in other herpesviruses, with an emphasis on viral and host factors that regulate this process.

Indexed as

Cell NucleusCytomegalovirusDNA, ViralHerpesviridaeHost-Derived Cellular FactorsHost-Pathogen InteractionsHumansNucleocapsidVirus ReplicationDNA, ViralHost-Derived Cellular Factors

Identifiers

PMID22633075
PMCPMC3408842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.