ArticlePsychiatry research2012
Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients.
Article in Psychiatry research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Peripheral blood brain-derived neurotrophic factor in bipolar disorder: a comprehensive systematic review and meta-analysis.Molecular psychiatry · 2016Pooled it
- Borderline personality: revisiting its classification as a neurodevelopmental disorder.Frontiers in psychiatry · 2025Review
- Possible roles of neuropeptide/transmitter and autoantibody modulation in emotional problems and aggression.Frontiers in psychiatry · 2024Review
- Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders.Neuronal signaling · 2023Review
- Oxidative stress and inflammatory process in borderline personality disorder (BPD): a narrative review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Review
- Protein and mRNA expression of protein kinase C (PKC) in the postmortem brain of bipolar and schizophrenic subjects.Journal of psychiatric research · 2020Article
- Increased BDNF methylation in saliva, but not blood, of patients with borderline personality disorder.Clinical epigenetics · 2018Article
- Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer's disease.Translational psychiatry · 2017Article
- Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms.BMC psychiatry · 2017Review
- Brain-derived neurotrophic factor Val66Met genotype modulates amygdala habituation.Psychiatry research. Neuroimaging · 2017Article
- BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis.Behavioral and brain functions : BBF · 2016Review
- Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2016Article
- Calcium-dependent intracellular signal pathways in primary cultured adipocytes and ANK3 gene variation in patients with bipolar disorder and healthy controls.Molecular psychiatry · 2015Article
- Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene.Translational psychiatry · 2013Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Borderline personality disorder (BPD) is a prevalent and difficult to treat psychiatric condition characterized by abrupt mood swings, intense anger and depression, unstable interpersonal relationships, impulsive self-destructive behavior and a suicide rate of approximately 10%. Possible underlying molecular dysregulations in BPD have not been well explored. Protein kinase C (PKC) and brain-derived neurotrophic factor (BDNF) have both been implicated in affective disorders, but their role in BPD has not been examined. Platelets were isolated from blood obtained from 24 medication-free BPD patients and 18 healthy control subjects. PKC-α, phosphorylated-PKC-α (p-PKCα), PKC-βII, and BDNF were measured in platelet homogenates by immunoblotting. In the males, platelet BDNF and PKC-α levels were lower in patients than controls. p-PKC-α and PKC-βII were lower at trend levels. In the entire sample, platelet p-PKCα and PKC-α activity were lower, at a trend level, in patients compared to controls. This is the first report to our knowledge of PKC and BDNF activity in BPD and calls for replication. These findings are consistent with altered PKC and BDNF activity in a range of neuropsychiatric conditions including bipolar disorder, depression and suicide.
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Registered trials
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