ArticleCell2012
Contact chemoreceptors mediate male-male repulsion and male-female attraction during Drosophila courtship.
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers.
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Who cites it
200 citing papers in PubMed, 374 citations in OpenAlex.
- Mating imperatives drive plasticity of the daily temporal niche in fruit flies.Nature ecology & evolution · 2026Article
- Convergent olfactory circuits for courtship in Drosophila revealed by the circuit-tracing tool ds-Tango.Current biology : CB · 2026Article
- Distinct ppk-expressing Neurons Oppositely Regulate Sexual Receptivity in Drosophila Females.Neuroscience bulletin · 2026Article
- Cross-Species Social Experience Suppresses Aggression in Drosophila.Neuroscience bulletin · 2026Article
- Article
- Evolutionary basis of male same-sex sexual behavior by multiple pheromone switches in Drosophila.Current biology : CB · 2026Article
- Visual recognition of the anteroposterior female body axis drives spatial elements of male courtship in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Article
- Strain variation identifies a neural substrate for behavioral evolution in Drosophila.Current biology : CB · 2026Article
- Feeding decision-making by a single neuron via disparate neurotransmitters.Nature communications · 2026Article
- Pickpocket315 affects male mating behavior in the yellow fever mosquito Aedes aegypti.G3 (Bethesda, Md.) · 2026Article
- Multisensory integration for active mechanosensation in Drosophila flight.Current biology : CB · 2026Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Evolutionary basis of intermale sexual behavior by multiple pheromone switches inbioRxiv : the preprint server for biology · 2025Article
- Gal4 drivers of the geosmin receptor Or56a exhibit ectopic expression in the labral sense organ of Drosophila.Scientific reports · 2025Article
- Strain variation identifies a neural substrate for behavioral evolution inbioRxiv : the preprint server for biology · 2025Article
- Gustatory receptors interact with the serotonin pathway to regulate silkmoth stereotyped courtship behavior.BMC biology · 2025Article
- Antennal RNAseq reveals odorant receptors with sex-biased expression in the common eastern firefly, Photinus pyralis.BMC genomics · 2025Article
- Article
- Sexually-dimorphic neurons in theResearch square · 2025Article
140 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The elaborate courtship ritual of Drosophila males is dictated by neural circuitry established by the transcription factor Fruitless and triggered by sex-specific sensory cues. Deciphering the role of different stimuli in driving courtship behavior has been limited by the inability to selectively target appropriate sensory classes. Here, we identify two ion channel genes belonging to the degenerin/epithelial sodium channel/pickpocket (ppk) family, ppk23 and ppk29, which are expressed in fruitless-positive neurons on the legs and are essential for courtship. Gene loss-of-function, cell-inactivation, and cell-activation experiments demonstrate that these genes and neurons are necessary and sufficient to inhibit courtship toward males and promote courtship toward females. Moreover, these cells respond to cuticular hydrocarbons, with different cells selectively responding to male or female pheromones. These studies identify a large population of pheromone-sensing neurons and demonstrate the essential role of contact chemosensation in the early courtship steps of mate selection and courtship initiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.