ReviewNeuron2012
How we feel: ion channel partnerships that detect mechanical inputs and give rise to touch and pain perception.
Review in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 106 citations in OpenAlex.
- A self-administered method of acute pressure block of sciatic nerves for short-term relief of dental pain: a randomized study.Pain medicine (Malden, Mass.) · 2014Trial
- Continuum tactile sensing via an amplified liquid metal interface.Science advances · 2026Article
- Interlocked transcription factor feedback loops maintain and restore adult touch sensation.Cell reports · 2026Article
- Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade.Cell reports · 2026Article
- The Effects of Whole-Body Vibration on Spasticity in Stroke: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Mechanical memory of excitable cells induced by mechanosensitive channel inactivation.Biophysical journal · 2025Article
- TheThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Acid-Sensing Ion Channels Drive the Generation of Tactile Impulses in Merkel Cell-Neurite Complexes of the Glabrous Skin of Rodent Hindpaws.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Shear stress sensing in C. elegans.Current biology : CB · 2024Article
- Piezo2 voltage-block regulates mechanical pain sensitivity.Brain : a journal of neurology · 2024Article
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- The topographical attenuation of cutaneous input is modulated at the ankle joint during gait.Experimental brain research · 2024Article
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- Article
- What is it like to be a choanoflagellate? Sensation, processing and behavior in the closest unicellular relatives of animals.Animal cognition · 2023Review
- Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis.Nature communications · 2023Article
- Review
- βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole.American journal of physiology. Renal physiology · 2022Article
- Ultrasound does not activate but can inhibit in vivo mammalian nerves across a wide range of parameters.Scientific reports · 2022Article
- C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation.The Journal of general physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Every moment of every day, our skin and its embedded sensory neurons are bombarded with mechanical cues that we experience as pleasant or painful. Knowing the difference between innocuous and noxious mechanical stimuli is critical for survival and relies on the function of mechanoreceptor neurons that vary in their size, shape, and sensitivity. Their function is poorly understood at the molecular level. This review emphasizes the importance of integrating analysis at the molecular and cellular levels and focuses on the discovery of ion channel proteins coexpressed in the mechanoreceptors of worms, flies, and mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.