ArticleCNS neuroscience & therapeutics2012
Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice.
Article in CNS neuroscience & therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Crocus Sativus for Insomnia: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Effects of Saffron Extract on Sleep Quality: A Randomized Double-Blind Controlled Clinical Trial.Nutrients · 2021Trial
- Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Trial
- GABALAGEN Facilitates Pentobarbital-Induced Sleep by Modulating the Serotonergic System in Rats.Current issues in molecular biology · 2024Article
- Application of the relative molar sensitivity method using GC-FID to quantify safranal in saffron (Crocus sativus L.).Journal of natural medicines · 2023Article
- Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice.Scientific reports · 2021Article
- A Novel Pharmacological Protective Role for Safranal in an Animal Model of Huntington's Disease.Neurochemical research · 2021Article
- Triphlorethol A, a Dietary Polyphenol from Seaweed, Decreases Sleep Latency and Increases Non-Rapid Eye Movement Sleep in Mice.Marine drugs · 2018Article
- Dietary Zinc Acts as a Sleep Modulator.International journal of molecular sciences · 2017Review
- Sleep-Promoting Effects and Possible Mechanisms of Action Associated with a Standardized Rice Bran Supplement.Nutrients · 2017Article
- Rosmarinic Acid Potentiates Pentobarbital-Induced Sleep Behaviors and Non-Rapid Eye Movement (NREM) Sleep through the Activation of GABABiomolecules & therapeutics · 2017Article
- Razi's Al-Hawi and saffron (Crocus sativus): a review.Iranian journal of basic medical sciences · 2015Review
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- Article
- Protective Effect of Safranal, a Constituent of Crocus sativus, on Quinolinic Acid-induced Oxidative Damage in Rat Hippocampus.Iranian journal of basic medical sciences · 2013Article
- Safranal: from an aromatic natural product to a rewarding pharmacological agent.Iranian journal of basic medical sciences · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsSafranal (2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde, C(10) H(14) O) is an active ingredient in the saffron, which is used in traditional medicine. It has been reported to have sedative and anti-epileptic effects, but its hypnotic effects remain uncertain. The aim of this study was to evaluate effects of safranal on sleep-wake cycle.
methodsWe established hypnotic-model mice treated with a low dose of pentobarbital 20 mg/kg, and administered different doses of safranal, vehicle, or diazepam. The change of sleep-wake cycle was assessed by sleep recording and c-Fos expression in the brain was analyzed by immunohistochemistry.
resultsSafranal increased the duration of non-rapid eye movement (NREM) sleep, shortened NREM sleep latency, and enhanced the delta power activity of NREM sleep. Immunohistochemical evaluation revealed that safranal increased c-Fos expression in the ventrolateral preoptic nucleus (VLPO), one of the putative sleep centers, and decreased it in the arousal histaminergic tuberomammillary nuclei (TMN).
conclusionThese findings indicate that safranal enhances NREM sleep in pentobarbital-treated mice. The hypnotic effects of safranal may be related to the activation of the sleep-promoting neurons in the VLPO and the simultaneous inhibition of the wakefulness-promoting neurons in the TMN, suggesting that safranal may be a hypnotic substance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.