ArticleBMC neurology2012
Altered small-world properties of gray matter networks in breast cancer.
Article in BMC neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Structural brain alterations following adult non-CNS cancers: a systematic review of the neuroimaging literature.Acta oncologica (Stockholm, Sweden) · 2019Pooled it
- Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors.Clinical breast cancer · 2013Trial
- Seeing through "brain fog": neuroimaging assessment and imaging biomarkers for cancer-related cognitive impairments.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Review
- Altered gyrification in chemotherapy-treated older long-term breast cancer survivors.Brain and behavior · 2024Article
- Volume-based structural connectome of epilepsy partialis continua in Rasmussen's encephalitis.Brain communications · 2024Article
- Cortical structural network characteristics in non-cognitive impairment end-stage renal disease.Frontiers in neuroscience · 2024Article
- Brain gray matter reduction and premature brain aging after breast cancer chemotherapy: a longitudinal multicenter data pooling analysis.Brain imaging and behavior · 2023Article
- Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRI.Frontiers in psychiatry · 2023Article
- Cognitive impairment and associations with structural brain networks, endocrine status, and risk genotypes in newly orchiectomized testicular cancer patients.Brain imaging and behavior · 2022Article
- Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events.Archives of toxicology · 2022Review
- Longitudinal Trajectories of Memory Performance in Patients with Early-Stage Breast Cancer.Journal of oncology · 2022Article
- Changes in Degree Centrality and Functional Connectivity after the First Cycle of Neoadjuvant Chemotherapy in Newly Diagnosed Breast Cancer: A Longitudinal Study.Disease markers · 2022Article
- Classification and Visualization of Chemotherapy-Induced Cognitive Impairment in Volumetric Convolutional Neural Networks.Journal of personalized medicine · 2021Article
- Donepezil Protects Against Doxorubicin-Induced Chemobrain in Rats via Attenuation of Inflammation and Oxidative Stress Without Interfering With Doxorubicin Efficacy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy.Scientific reports · 2021Article
- Cancer-related cognitive impairment in patients with non-central nervous system malignancies: an overview for oncology providers from the MASCC Neurological Complications Study Group.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Review
- Structural Neuroimaging Findings Related to Adult Non-CNS Cancer and Treatment: Review, Integration, and Implications for Treatment of Cognitive Dysfunction.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Chemotherapy-Induced Brain Effects in Small-Cell Lung Cancer Patients: A Multimodal MRI Study.Brain topography · 2021Article
- Altered Brain Functional Network Topology in Lung Cancer Patients After Chemotherapy.Frontiers in neurology · 2021Article
- Cross-Sectional Characterization of Local Brain Network Connectivity Pre and Post Breast Cancer Treatment and Distinct Association With Subjective Cognitive and Psychological Function.Frontiers in neurology · 2021Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBreast cancer survivors, particularly those treated with chemotherapy, are at significantly increased risk for long-term cognitive and neurobiologic impairments. These deficits tend to involve skills that are subserved by distributed brain networks. Additionally, neuroimaging studies have shown a diffuse pattern of brain structure changes in chemotherapy-treated breast cancer survivors that might impact large-scale brain networks.
methodsWe therefore applied graph theoretical analysis to compare the gray matter structural networks of female breast cancer survivors with a history of chemotherapy treatment and healthy age and education matched female controls.
resultsResults revealed reduced clustering coefficient and small-world index in the brain network of the breast cancer patients across a range of network densities. In addition, the network of the breast cancer group had less highly interactive nodes and reduced degree/centrality in the frontotemporal regions compared to controls, which may help explain the common impairments of memory and executive functioning among these patients.
conclusionsThese results suggest that breast cancer and chemotherapy may decrease regional connectivity as well as global network organization and integration, reducing efficiency of the network. To our knowledge, this is the first report of altered large-scale brain networks associated with breast cancer and chemotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.