ArticlePloS one2012
The MSX1 homeoprotein recruits G9a methyltransferase to repressed target genes in myoblast cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Aberrant MNX1 expression associated with t(7;12)(q36;p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation.Haematologica · 2024Article
- Retraction: The Msx1 Homeoprotein Recruits G9a Methyltransferase to Repressed Target Genes in Myoblast Cells.PloS one · 2023Article
- Global Quantitative Proteomics Analysis Reveals the Downstream Signaling Networks of Msx1 and Msx2 in Myoblast Differentiation.Phenomics (Cham, Switzerland) · 2022Article
- Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery.Frontiers in cell and developmental biology · 2022Article
- Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration.Frontiers in cell and developmental biology · 2021Review
- (Epi)genetic Modifications in Myogenic Stem Cells: From Novel Insights to Therapeutic Perspectives.Cells · 2019Review
- SUMOylation of G9a regulates its function as an activator of myoblast proliferation.Cell death & disease · 2019Article
- Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis.Cell & bioscience · 2019Article
- A drive in SUVs: From development to disease.Epigenetics · 2017Review
- G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation.Nucleic acids research · 2016Article
- Article
- Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation.Science (New York, N.Y.) · 2016Article
- Epigenetic Regulation of the Homeobox Gene MSX1 Associates with Platinum-Resistant Disease in High-Grade Serous Epithelial Ovarian Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- Concise Review: Epigenetic Regulation of Myogenesis in Health and Disease.Stem cells translational medicine · 2016Review
- Role of MSX1 in Osteogenic Differentiation of Human Dental Pulp Stem Cells.Stem cells international · 2016Article
- Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer.Biology open · 2015Article
- Conserved Cis-Regulatory Modules Control Robustness in Msx1 Expression at Single-Cell Resolution.Genome biology and evolution · 2015Article
- Sound of silence: the properties and functions of repressive Lys methyltransferases.Nature reviews. Molecular cell biology · 2015Review
- Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus.The Journal of biological chemistry · 2015Article
- Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2.Antioxidants & redox signaling · 2015Review
Corrections and comments
- Retraction · 2023-07-05Concerns/Issues about Image · Duplication of/in Image · Original Data and/or Images not Provided and/or not Available · · see also: https://pubpeer.com/publications/6B85A3BD7232ADBF0FE517780B7E10#6
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although the significance of lysine modifications of core histones for regulating gene expression is widely appreciated, the mechanisms by which these modifications are incorporated at specific regulatory elements during cellular differentiation remains largely unknown. In our previous studies, we have shown that in developing myoblasts the Msx1 homeoprotein represses gene expression by influencing the modification status of chromatin at its target genes. We now show that genomic binding by Msx1 promotes enrichment of the H3K9me2 mark on repressed target genes via recruitment of G9a histone methyltransferase, the enzyme responsible for catalyzing this histone mark. Interaction of Msx1 with G9a is mediated via the homeodomain and is required for transcriptional repression and regulation of cellular differentiation, as well as enrichment of the H3K9me2 mark in proximity to Msx1 binding sites on repressed target genes in myoblast cells as well as the developing limb. We propose that regulation of chromatin status by Msx1 recruitment of G9a and other histone modifying enzymes to regulatory regions of target genes represents an important means of regulating the gene expression during development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.