ArticlePloS one2012
A quantitative 3D motility analysis of Trypanosoma brucei by use of digital in-line holographic microscopy.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Digital in-line holographic microscopy for label-free identification and tracking of biological cells.Military Medical Research · 2024Review
- Trajectory-driven computational analysis for element characterization in Trypanosoma cruzi video microscopy.PloS one · 2024Article
- Article
- Revealing spatio-temporal dynamics with long-term trypanosomatid live-cell imaging.PLoS pathogens · 2022Article
- Engineered topographies and hydrodynamics in relation to biofouling control-a review.Environmental science and pollution research international · 2021Review
- Multifocal imaging for precise, label-free tracking of fast biological processes in 3D.Nature communications · 2021Article
- High-speed, three-dimensional imaging reveals chemotactic behaviour specific to human-infectiveeLife · 2021Article
- Motility Analysis of Trypanosomatids.Methods in molecular biology (Clifton, N.J.) · 2020Article
- If host is refractory, insistent parasite goes berserk: Trypanosomatid Blastocrithidia raabei in the dock bug Coreus marginatus.PloS one · 2020Article
- Use of chiral cell shape to ensure highly directional swimming in trypanosomes.PLoS computational biology · 2017Article
- Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies.PLoS pathogens · 2016Article
- Species-Specific Adaptations of Trypanosome Morphology and Motility to the Mammalian Host.PLoS pathogens · 2016Article
- Simulating the complex cell design of Trypanosoma brucei and its motility.PLoS computational biology · 2015Article
- Knockdown of Inner Arm Protein IC138 in Trypanosoma brucei Causes Defective Motility and Flagellar Detachment.PloS one · 2015Article
- Experimental and Mathematical-Modeling Characterization of Trypanosoma cruzi Epimastigote Motility.PloS one · 2015Article
- Mouse infection and pathogenesis by Trypanosoma brucei motility mutants.Cellular microbiology · 2014Article
- Unlocking the secrets of multi-flagellated propulsion: drawing insights from Tritrichomonas foetus.Journal of the Royal Society, Interface · 2014Article
- Article
- The limits on trypanosomatid morphological diversity.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a quantitative 3D analysis of the motility of the blood parasite Trypanosoma brucei. Digital in-line holographic microscopy has been used to track single cells with high temporal and spatial accuracy to obtain quantitative data on their behavior. Comparing bloodstream form and insect form trypanosomes as well as mutant and wildtype cells under varying external conditions we were able to derive a general two-state-run-and-tumble-model for trypanosome motility. Differences in the motility of distinct strains indicate that adaption of the trypanosomes to their natural environments involves a change in their mode of swimming.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.