ArticlePloS one2012
The expression of small regulatory RNAs in clinical samples reflects the different life styles of Staphylococcus aureus in colonization vs. infection.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Thirty Years of sRNA-Mediated Regulation inInternational journal of molecular sciences · 2022Review
- Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions.Frontiers in cellular and infection microbiology · 2022Review
- Article
- Adaptive expression of biofilm regulators and adhesion factors ofExperimental and therapeutic medicine · 2020Article
- RNA-Sequencing Analyses of Small Bacterial RNAs and their Emergence as Virulence Factors in Host-Pathogen Interactions.International journal of molecular sciences · 2020Review
- Insight into the Effect of Small RNAIndian journal of microbiology · 2019Article
- A Mn-sensing riboswitch activates expression of a Mn2+/Ca2+ ATPase transporter in Streptococcus.Nucleic acids research · 2019Article
- Noncoding RNA.Microbiology spectrum · 2019Review
- The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus.Nucleic acids research · 2018Article
- Small RNA-Based Regulation of Bacterial Quorum Sensing and Biofilm Formation.Microbiology spectrum · 2018Review
- High-throughput sequencing identification and characterization of potentially adhesion-related small RNAs in Streptococcus mutans.Journal of medical microbiology · 2018Article
- sRNA and cis-antisense sRNA identification in Staphylococcus aureus highlights an unusual sRNA gene cluster with one encoding a secreted peptide.Scientific reports · 2017Article
- Potential and use of bacterial small RNAs to combat drug resistance: a systematic review.Infection and drug resistance · 2017Review
- Staphylococcus aureus Regulatory RNAs as Potential Biomarkers for Bloodstream Infections.Emerging infectious diseases · 2016Article
- A defense-offense multi-layered regulatory switch in a pathogenic bacterium.Nucleic acids research · 2015Article
- A nitric oxide regulated small RNA controls expression of genes involved in redox homeostasis in Bacillus subtilis.PLoS genetics · 2015Article
- A non-coding RNA promotes bacterial persistence and decreases virulence by regulating a regulator in Staphylococcus aureus.PLoS pathogens · 2014Article
- RNA-mediated regulation in pathogenic bacteria.Cold Spring Harbor perspectives in medicine · 2013Review
- Emerging functions for the Staphylococcus aureus RNome.PLoS pathogens · 2013Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small RNAs (sRNAs) are involved in the post-transcriptional regulation of metabolic pathways and in responses to stress and virulence. We analyzed the expression levels of five sRNAs of Staphylococcus aureus during human colonization or infection. Total RNA was isolated from nasal carriers, abscesses and cystic fibrosis patients (20 subjects per condition). The expression levels of the sRNAs were measured in the clinical samples and compared with those of the corresponding strains grown in vitro. Five sRNAs were encoded and expressed in all clinical strains in vitro. In vivo, the global expression of the five sRNAs was extremely variable in the abscessed patients, more homogeneous in the cystic fibrosis patients, and highly uniform in the nasal carrier samples. The expression levels of the sRNAs in vivo resembled those obtained at exponential phase or late exponential phase of growth in vitro, for three and one sRNA respectively; while for one sRNA, the expression was always higher in vivo as compared to in vitro growth. The in vitro conditions do not uniformly mimic the in vivo conditions for sRNA expression. Nasal colonization is associated with a unique expression pattern of sRNA that might reflect the commensalism of S. aureus in this niche.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.