ArticleFrontiers in genetics2012
The Path to microRNA Therapeutics in Psychiatric and Neurodegenerative Disorders.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Stress, microRNAs, and stress-related psychiatric disorders: an overview.Molecular psychiatry · 2023Review
- MicroRNA Networks in Cognition and Dementia.Cells · 2022Review
- MicroRNA-6862 inhibition elevates sphingosine kinase 1 and protects neuronal cells from MPPAging · 2020Article
- The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells.Nature communications · 2020Article
- microRNAs Sculpt Neuronal Communication in a Tight Balance That Is Lost in Neurological Disease.Frontiers in molecular neuroscience · 2018Review
- Small RNAs May Answer Big Questions in Mental Illness.Biological psychiatry · 2018Article
- Potential Roles of microRNAs in the Regulation of Monoamine Oxidase A in the Brain.Frontiers in molecular neuroscience · 2018Review
- MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.The international journal of neuropsychopharmacology · 2016Article
- Tissue-specific and plasma microRNA profiles could be promising biomarkers of histological classification and TNM stage in non-small cell lung cancer.Thoracic cancer · 2016Article
- miR-196a Ameliorates Cytotoxicity and Cellular Phenotype in Transgenic Huntington's Disease Monkey Neural Cells.PloS one · 2016Article
- microRNA Profiles in Parkinson's Disease Prefrontal Cortex.Frontiers in aging neuroscience · 2016Article
- Noncoding RNA Regulation of Dopamine Signaling in Diseases of the Central Nervous System.Frontiers in molecular biosciences · 2016Review
- Profiling olfactory stem cells from living patients identifies miRNAs relevant for autism pathophysiology.Molecular autism · 2016Article
- The MiRNA Journey from Theory to Practice as a CNS Biomarker.Frontiers in genetics · 2016Review
- miRNAs: Key Players in Neurodegenerative Disorders and Epilepsy.Journal of Alzheimer's disease : JAD · 2015Review
- Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- microRNA-128a dysregulation in transgenic Huntington's disease monkeys.Molecular brain · 2014Article
- MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease.Neuroscience bulletin · 2014Article
- Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications.Dialogues in clinical neuroscience · 2014Review
- Impulsivity and comorbid traits: a multi-step approach for finding putative responsible microRNAs in the amygdala.Frontiers in neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The microRNA (miRNA) class of non-coding RNAs exhibit a diverse range of regulatory roles in neuronal functions that are conserved from lower vertebrates to primates. Disruption of miRNA expression has compellingly been linked to pathogenesis in neuropsychiatric and neurodegenerative disorders, such as schizophrenia, Alzheimer's disease, and autism. The list of transcript targets governed by a single miRNA provide a molecular paradigm applicable for therapeutic intervention. Indeed, reports have shown that specific manipulation of a miRNA in cell or animal models can significantly alter phenotypes linked with neurological disease. Here, we review how a diverse range of biological systems, including Drosophila, rodents, and primates such as monkeys and humans, can be integrated into the translation of miRNAs as novel clinical targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.