ArticleTheScientificWorldJournal2012
Diet-induced swine model with obesity/leptin resistance for the study of metabolic syndrome and type 2 diabetes.
Article in TheScientificWorldJournal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Article
- Obesity as Inducer of Cognitive Function Decline via Dysbiosis of Gut Microbiota in Rats.Brain sciences · 2024Article
- Maternal dietary antioxidant supplementation regulates weaned piglets' adipose tissue transcriptome and morphology.PloS one · 2024Article
- Metabolic Profile of Growing Immune- and Surgically Castrated Iberian Pigs Fed Diets of Different Amino Acid Concentration.Animals : an open access journal from MDPI · 2023Article
- Obesity and Metabolic Traits after High-Fat Diet in Iberian Pigs with Low Birth Weight of Placental Origin.Biology · 2022Article
- A High-Fat Diet Modifies Brain Neurotransmitter Profile and Hippocampal Proteome and Morphology in an IUGR Pig Model.Nutrients · 2022Article
- Brachial plexus anatomy in the miniature swine as compared to human.Journal of anatomy · 2022Article
- Article
- Changes inAnimals : an open access journal from MDPI · 2021Article
- Feeding Crude Glycerin to Finishing Iberian Crossbred Pigs: Effects on Growth Performance, Nutrient Digestibility, and Blood Parameters.Animals : an open access journal from MDPI · 2021Article
- Consumption of High-Fructose Corn Syrup Compared with Sucrose Promotes Adiposity and Increased Triglyceridemia but Comparable NAFLD Severity in Juvenile Iberian Pigs.The Journal of nutrition · 2021Article
- Muscle Transcriptome Analysis Reveals Molecular Pathways Related to Oxidative Phosphorylation, Antioxidant Defense, Fatness and Growth in Mangalitsa and Moravka Pigs.Animals : an open access journal from MDPI · 2021Article
- Determining insulin sensitivity from glucose tolerance tests in Iberian and landrace pigs.PeerJ · 2021Article
- Article
- Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring.Animals : an open access journal from MDPI · 2020Article
- Article
- Metformin Alleviates Obesity and Systemic Oxidative Stress in Obese Young Swine.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Differential Effects of Litter Size and Within-Litter Birthweight on Postnatal Traits of Fatty Pigs.Animals : an open access journal from MDPI · 2020Article
- Comparative Transcriptomic Analysis of Subcutaneous Adipose Tissue from Local Pig Breeds.Genes · 2020Article
- A Cross-Sectional Study of Obesity Effects on the Metabolomic Profile of a Leptin-Resistant Swine Model.Metabolites · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the present study was to determine the suitability of a swine breed with leptin resistance and predisposition to obesity (the Iberian pig) as model for studies on metabolic syndrome and type 2 diabetes. Thus, six Iberian sows had ad libitum access to food enriched with saturated fat (SFAD group; food consumption was estimated to be 4.5 kg/animal/day) whilst four females acted as controls and were fed with 2 kg/animal/day of a commercial maintenance diet. After three months of differential feeding, SFAD animals developed central obesity, dyslipidemia, insulin resistance and impaired glucose tolerance, and elevated blood pressure; the five parameters associated with the metabolic syndrome. Thus, the current study characterizes the Iberian pig as a robust, amenable, and reliable translational model for studies on nutrition-associated diseases.
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