ArticleJournal of pharmacology & pharmacotherapeutics2012
Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice.
Article in Journal of pharmacology & pharmacotherapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 96 citations in OpenAlex.
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- Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms.Molecules (Basel, Switzerland) · 2022Review
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- Biomedical Applications and Bioavailability of Curcumin-An Updated Overview.Pharmaceutics · 2021Review
- Novel Therapies for the Treatment of Drug-Induced Liver Injury: A Systematic Review.Frontiers in pharmacology · 2021Review
- Protective Effects of Ellagic Acid Against Alcoholic Liver Disease in Mice.Frontiers in nutrition · 2021Article
- Hepatoprotective Plants from Bangladesh: A Biophytochemical Review and Future Prospect.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Aceclofenac-induced hepatotoxicity: An ameliorative effect ofWorld journal of hepatology · 2020Article
- The Effects of Natural Iridoids and Anthocyanins on Selected Parameters of Liver and Cardiovascular System Functions.Oxidative medicine and cellular longevity · 2020Review
- Curcumin Attenuates the Pathogenicity ofPathogens (Basel, Switzerland) · 2019Article
- Nanoliposome-encapsulated ellagic acid prevents cyclophosphamide-induced rat liver damage.Molecular and cellular biochemistry · 2019Article
- Effect of Extract and Ellagic Acid fromAntioxidants (Basel, Switzerland) · 2018Article
- Ellagic acid in suppressing in vivo and in vitro oxidative stresses.Molecular and cellular biochemistry · 2018Review
- Role of Curcumin in Disease Prevention and Treatment.Advanced biomedical research · 2018Review
- Antioxidant and hepatoprotective effects ofJournal of traditional and complementary medicine · 2018Article
- Exploratory Studies of (-)-Epicatechin, a Bioactive Compound ofPharmacognosy magazine · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo evaluate the hepatoprotective activity of active phytochemicals, picroliv, curcumin, and ellagic acid in comparison to silymarin in the mice model of carbon tetrachloride (CCl(4)) induced liver toxicity. In addition, attempts were made to elucidate their possible mechanism(s) of action. MATERIALS AND
methodsOxidative stress was induced in Swiss albino mice by a single injection (s.c.) of CCl(4), 1 ml/kg body weight, diluted with arachis oil at a 1:1 ratio. The phytochemicals were administered once a day for 7& days (p.o.) as pretreatment at two dose levels (50 and 100 mg/kg/day).
resultsCCl(4)-induced hepatotoxicity was manifested by an increase in the activities of liver enzymes (alanine transaminase, P < 0.001, aspartate transaminase, P < 0.001 and alkaline phosphatase, P < 0.001), malondialdehyde (MDA, P < 0.001)) levels and a decrease in activity of reduced glutathione (P < 0.001) and catalase in liver tissues. The histopathological examination of liver sections revealed centrizonal necrosis, fatty changes, and inflammatory reactions. The pretreatment with picroliv, curcumin, and ellagic acid normalized serum aminotransferase activities (P < 0.001), decreased levels of MDA (P < 0.001), improved the antioxidant status, and normalized the hepatic histo-architecture. The restoration of phenobarbitone-induced sleeping time also suggested the normalization of liver cytochrome P450 enzymes.
conclusionThis study supports the use of these active phytochemicals against toxic liver injury, which may act by preventing lipid peroxidation, augmenting the antioxidant defense system or by regenerating the hepatocytes.
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