ArticleJournal of the Royal Society, Interface2012
Post-secretion processing influences spider silk performance.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Meta-analysis reveals materiomic relationships in major ampullate silk across the spider phylogeny.Journal of the Royal Society, Interface · 2020Pooled it
- Triangle weaver spiders construct spring-loaded webs using a novel set of genes for exceptionally proline-rich silk.PNAS nexus · 2025Article
- Progress in Multiscale Modeling of Silk Materials.Biomacromolecules · 2024Review
- Influence of experimental methods on the mechanical properties of silk fibers: A systematic literature review and future road map.Biophysics reviews · 2023Review
- Relating spidroin motif prevalence and periodicity to the mechanical properties of major ampullate spider silks.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Darwin's bark spider shares a spidroin repertoire withOpen biology · 2021Article
- Correlation between protein secondary structure and mechanical performance for the ultra-tough dragline silk of Darwin's bark spider.Journal of the Royal Society, Interface · 2021Article
- Xanthurenic Acid Is the Main Pigment ofBiomolecules · 2021Article
- Small behavioral adaptations enable more effective prey capture by producing 3D-structured spider threads.Scientific reports · 2019Article
- A Facile Measurement for Monitoring Dragline Silk Dope Concentration inMaterials (Basel, Switzerland) · 2018Article
- Major Ampullate Spider Silk with Indistinguishable Spidroin Dope Conformations Leads to Different Fiber Molecular Structures.International journal of molecular sciences · 2016Article
- Evidence of Decoupling Protein Structure from Spidroin Expression in Spider Dragline Silks.International journal of molecular sciences · 2016Article
- Spider web and silk performance landscapes across nutrient space.Scientific reports · 2016Article
- Intrinsic tensile properties of cocoon silk fibres can be estimated by removing flaws through repeated tensile tests.Journal of the Royal Society, Interface · 2015Article
- Nephila clavipes Flagelliform silk-like GGX motifs contribute to extensibility and spacer motifs contribute to strength in synthetic spider silk fibers.Biomacromolecules · 2013Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotypic variation facilitates adaptations to novel environments. Silk is an example of a highly variable biomaterial. The two-spidroin (MaSp) model suggests that spider major ampullate (MA) silk is composed of two proteins-MaSp1 predominately contains alanine and glycine and forms strength enhancing β-sheet crystals, while MaSp2 contains proline and forms elastic spirals. Nonetheless, mechanical properties can vary in spider silks without congruent amino acid compositional changes. We predicted that post-secretion processing causes variation in the mechanical performance of wild MA silk independent of protein composition or spinning speed across 10 species of spider. We used supercontraction to remove post-secretion effects and compared the mechanics of silk in this 'ground state' with wild native silks. Native silk mechanics varied less among species compared with 'ground state' silks. Variability in the mechanics of 'ground state' silks was associated with proline composition. However, variability in native silks did not. We attribute interspecific similarities in the mechanical properties of native silks, regardless of amino acid compositions, to glandular processes altering molecular alignment of the proteins prior to extrusion. Such post-secretion processing may enable MA silk to maintain functionality across environments, facilitating its function as a component of an insect-catching web.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.