Evidence map›Paper›PMID 22628113›Full record

ReviewStem cell reviews and reports2012

The evolving role of the aryl hydrocarbon receptor (AHR) in the normophysiology of hematopoiesis.

Stephan Lindsey, Eleftherios T Papoutsakis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell reviews and reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Elevated circulating bile acids driven erythrocyte osmotic resistance marks hepatobiliary disease.American journal of physiology. Gastrointestinal and liver physiology · 2026
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  13. Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  14. Developmental Regulation of Nuclear Factor Erythroid-2 Related Factors (nrfs) by AHR1b in Zebrafish (Danio rerio).Toxicological sciences : an official journal of the Society of Toxicology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stephan LindseyDepartment of Chemical & Biomolecular Engineering, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA. slindsey@udel.edu
Eleftherios T Papoutsakis

Funding

Role of shear forces in proplatelet production from stem cells in bioreactorsR21HL106397 · NHLBI · UNIVERSITY OF DELAWARE · PI PAPOUTSAKIS, ELEFTHERIOS T · 2011 to 2012
$405k
Role of AhR During MegakaryopoiesisF32HL091620 · NHLBI · UNIVERSITY OF DELAWARE · PI LINDSEY, STEPHAN CADET · 2009 to 2011
$157k
NHLBI NIH HHS F32 HL091620NHLBI NIH HHS F32HL091620NHLBI NIH HHS R21 HL106397NHLBI NIH HHS R21HL106397
6 · The paper itself

Abstract

In addition to its role as a toxicological signal mediator, the Aryl Hydrocarbon Receptor (AHR) is also a transcription factor known to regulate cellular responses to oxidative stress and inflammation through transcriptional regulation of molecules involved in the signaling of nucear factor-erythroid 2-related factor-2 (Nrf2), p53 (TRP53), retinoblastoma (RB1), and NFκB. Recent research suggests that AHR activation of these signaling pathways may provide the molecular basis for understanding AHR's evolving role in endogenous developmental functions during hematopoietic stem-cell maintenance and differentiation. Recent developments into the hematopoietic roles for AHR are reviewed, aiming to reconcile divergent findings as to the endogenous function of AHR in hematopoiesis. Potential mechanistic explanations for AHR's involvement in hematopoietic differentiation are discussed, focusing on its known role as a cell cycle mediator and its interactions with Hypoxia-inducible transcription factor-1 alpha (HIF1-α). Understanding the physiological mechanisms of AHR activation and signaling have far reaching implications ranging from explaining the action of various toxicological agents to providing novel ways to expand stem cell populations ex vivo for use in transplant therapies.

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsHematopoiesisHematopoietic Stem CellsHumansHypoxia-Inducible Factor 1, alpha SubunitNF-E2-Related Factor 2NF-kappa BReceptors, Aryl HydrocarbonRetinoblastoma ProteinSignal TransductionTumor Suppressor Protein p53AHR protein, humanBasic Helix-Loop-Helix ProteinsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitNFE2L2 protein, humanNF-E2-Related Factor 2NF-kappa BReceptors, Aryl HydrocarbonRetinoblastoma ProteinTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID22628113
PMCPMC3463730

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.