ArticleChannels (Austin, Tex.)
The activity of the TRP-like channel depends on its expression system.
Article in Channels (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- The Role of Membrane Lipids in Light-Activation ofBiomolecules · 2022Review
- Modulation of Transient Receptor Potential C Channel Activity by Cholesterol.Frontiers in pharmacology · 2019Review
- Lipid signaling to membrane proteins: From second messengers to membrane domains and adapter-free endocytosis.The Journal of general physiology · 2018Review
- Diacylglycerol activates the light-dependent channel TRP in the photosensitive microvilli of Drosophila melanogaster photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- New insights into TRP channels: Interaction with pattern recognition receptors.Channels (Austin, Tex.) · 2014Review
- The genetic analysis of functional connectomics in Drosophila.Advances in genetics · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 3 countries.
Funding
Abstract
The Drosophila light activated TRP and TRPL channels have been a model for TRPC channel gating. Several gating mechanisms have been proposed following experiments conducted on photoreceptor and tissue cultured cells. However, conclusive evidence for any mechanism is still lacking. Here, we show that the Drosophila TRPL channel expressed in tissue cultured cells is constitutively active in S2 cells but is silent in HEK cells. Modulations of TRPL channel activity in different expression system by pharmacology or specific enzymes, which change the lipid content of the plasma membrane, resulted in conflicting effects. These findings demonstrate the difficulty in elucidating TRPC gating, as channel behavior is expression system dependent. However, clues on the gating mechanism may arise from understanding how different expression systems affect TRPC channel activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.