Evidence map›Paper›PMID 22627912›Full record

Trial reportObesity (Silver Spring, Md.)2012

Effect of diet composition and weight loss on resting energy expenditure in the POUNDS LOST study.

Lilian de Jonge, George A Bray, Steven R Smith, Donna H Ryan, Russell J de Souza, Catherine M Loria, Catherine M Champagne, Donald A Williamson, Frank M Sacks

Registry-linked trialAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04029532 (Factors Associated With Obesity in Adult Women), which is not on this map. Cited by 27 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04029532 completednot on this mapstarted 2019, after this paper: background citation

Factors Associated With Obesity in Adult Women: Respiratory Exchange Ratio, Heart Rate Variation and Body Image

TypeobservationalSponsorNational Taiwan University HospitalRan2019 to 2020Enrolled121ConditionsObesityArmsRespiratory exchange ratio, Heart rate variability, Body composition, Eating behavior, Physical activity recall
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  7. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  8. Effectiveness of weight loss interventions--is there a difference between men and women: a systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lilian de JongePennington Biomedical Research Center Baton Rouge, Baton Rouge, Louisiana, USA.
George A Bray
Steven R Smith
Donna H Ryan
Russell J de Souza
Catherine M Loria
Catherine M Champagne
Donald A Williamson
Frank M Sacks

Funding

Zoledronic Acid in Treatment of Osteoporosis in PostmenoM01RR002635 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI WELT, CORRINE K · 1985 to 2008
$48.4M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
Dietary Macronutrients and Weight LossU01HL073286 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SACKS, FRANK M · 2003 to 2008
$7.6M
NCRR NIH HHS M01 RR002635NCRR NIH HHS RR 02635NHLBI NIH HHS HL 073286NHLBI NIH HHS U01 HL073286NIDDK NIH HHS P30 DK072476
6 · The paper itself

Abstract

Weight loss reduces energy expenditure, but it is unclear whether dietary macronutrient composition affects this reduction. We hypothesized that energy expenditure might be modulated by macronutrient composition of the diet. The Prevention of Obesity Using Novel Dietary Strategies (POUNDS) LOST study, a prospective, randomized controlled trial in 811 overweight/obese people who were randomized in a 2 × 2 design to diets containing 20en% or 40en% fat and 15en% or 25en% protein (diets with 65%, 55%, 45%, and 35% carbohydrate) provided the data to test this hypothesis. Resting energy expenditure (REE) was measured at baseline, 6, and 24 months using a ventilated hood. REE declined at 6 months by 99.5 ± 8.0 kcal/day in men and 55.2 ± 10.6 kcal/day in women during the first 6 months. This decline was related to the weight loss, and there was no difference between the diets. REE had returned to baseline by 24 months, but body weight was still 60% below baseline. Measured REE at 6 months was significantly lower than the predicted (-18.2 ± 6.7 kcal/day) and was the result of significant reductions from baseline in the low-fat diets (65% or 55% carbohydrate), but not in the high fat diet groups. By 24 months the difference had reversed with measured REE being slightly but significantly higher than predicted (21.8 ± 10.1 kcal/day). In conclusion, we found that REE fell significantly after weight loss but was not related to diet composition. Adaptive thermogenesis was evident at 6 months, but not at 24 months.

Indexed as

Basal MetabolismDiet, ReducingWeight LossAdultAgedDietary FatsDietary ProteinsFemaleHumansMaleMiddle AgedObesityProspective StudiesRestDietary FatsDietary Proteins

Identifiers

PMID22627912
PMCPMC3760199

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.