Evidence map›Paper›PMID 22627862›Full record

ReviewNature reviews. Immunology2012

The impact of infection and tissue damage in solid-organ transplantation.

Anita S Chong, Maria-Luisa Alegre

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Innate Immune Memory Responses in Organ Transplantation.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Highlights on Advancing Frontiers in Tissue Engineering.Tissue engineering. Part B, Reviews · 2022
    Review
  12. Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Induction Therapy and Therapeutic Antibodies.Handbook of experimental pharmacology · 2022
    Article
  14. Article
  15. Epidemiology and outcomes of medically attended and microbiologically confirmed bacterial foodborne infections in solid organ transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  16. Review
  17. Review
  18. Early cytomegalovirus DNAemia and antiviral dose adjustment in high vs intermediate risk kidney transplant recipients.Transplant infectious disease : an official journal of the Transplantation Society · 2021
    Article
  19. Sterile inflammation in thoracic transplantation.Cellular and molecular life sciences : CMLS · 2021
    Review
  20. Apoptotic Donor Cells in Transplantation.Frontiers in immunology · 2021
    Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anita S ChongDepartment of Surgery, The University of Chicago, 5841 South Maryland Avenue, Chicago, Illinois 60637, USA. achong@surgery.bsd.uchicago.edu
Maria-Luisa Alegre
University of Chicago · US

Funding

T cell mechanisms that distinguish robust tolerance from metastable allograft acceptance and failed tolerance (Project 2)P01AI097113 · NIAID · UNIVERSITY OF CHICAGO · PI Maria-Luisa Alegre, Anita S Chong · 2012 to 2026
$23.8M
Mechanistic studies on Listeria infection and inhibition of allograft toleranceR01AI072630 · NIAID · UNIVERSITY OF CHICAGO · PI CHONG, ANITA S · 2007 to 2011
$2.1M
Mechanisms of TLR-mediated prevention of transplantation toleranceR01AI071080 · NIAID · UNIVERSITY OF CHICAGO · PI ALEGRE, MARIA-LUISA · 2008 to 2012
$1.6M
NIAID NIH HHS P01 AI097113NIAID NIH HHS R01 AI071080NIAID NIH HHS R01 AI072630
6 · The paper itself

Abstract

Investigations over the past two decades are revealing complexities in the regulation of the innate immune response, and how this response, in turn, controls adaptive immunity. Microbial exposure, infections and tissue damage that accompany solid-organ transplantation result in the release of pathogen- and damage-associated molecular patterns, as well as pathogen- or allograft-derived antigens. Here, we review these triggers of innate and adaptive immunity, and discuss emerging paradigms of the many ways in which infections and tissue damage might directly or indirectly affect alloreactivity and the outcome of transplanted allografts.

Indexed as

Organ TransplantationAdaptive ImmunityAnimalsGraft RejectionHumansImmunity, InnateInfectionsTransplants

Identifiers

PMID22627862
PMCPMC4053185
OpenAlexW2030855575

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.