ArticleCancer microenvironment : official journal of the International Cancer Microenvironment Society2012
Multifaceted tumor stromal fibroblasts.
Article in Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Stearoyl-CoA Desaturase-1 dependent lipid droplets accumulation in cancer-associated fibroblasts facilitates the progression of lung cancer.International journal of biological sciences · 2022Article
- The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation.International journal of molecular sciences · 2021Article
- Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment.Frontiers in oncology · 2014Review
- TNFR-1 on tumor cells contributes to the sensitivity of fibrosarcoma to chemotherapy.Protein & cell · 2013Article
- Transcription factor networks in invasion-promoting breast carcinoma-associated fibroblasts.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumors are highly complex tissues composed of neoplastic cells and different kinds of stromal cells. Tumor stromal cells, especially fibroblasts, play important roles during the multistep development of tumors. In this review, the two-faced characteristics of tumor stromal fibroblasts are discussed in the light of our current knowledge. For one thing, fibroblasts act as an "inflammation regulator" by secretion of cytokines and regulation of tumor immunity; for another, they act as a "damage healer" for cure of wounds by remodeling extracellular matrix or taking a part in the "foreign body reaction". Since the properties of fibroblasts are complicated, both aspects of fibroblasts for tumor development should be considered carefully in clinical studies to target cancer-associated fibroblasts.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.