ArticleDevelopment (Cambridge, England)2012
Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Functional genomics analysis of developing zebrafish and human endoderm reveals highly conservedGenome research · 2026Article
- Molecular and Functional Divergence of Zebrafish Sox Paralogs Controlling Endoderm Formation and Left-Right Patterning.Genome biology and evolution · 2025Article
- Developmental progression continues during embryonic diapause in the roe deer.Communications biology · 2024Article
- Single cell RNA analysis of the left-right organizer transcriptome reveals potential novel heterotaxy genes.Scientific reports · 2023Article
- Spectrum of Genetic Variants in a Cohort of 37 Laterality Defect Cases.Frontiers in genetics · 2022Article
- Signals and forces shaping organogenesis of the small intestine.Current topics in developmental biology · 2019Review
- Sox17 is essential for proper formation of the marginal zone of extraembryonic endoderm adjacent to a developing mouse placental disk.Biology of reproduction · 2018Article
- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids.Development (Cambridge, England) · 2017Article
- Left-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis.Trends in genetics : TIG · 2017Review
- Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left-right patterning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Roles of connexins and pannexins in digestive homeostasis.Cellular and molecular life sciences : CMLS · 2015Review
- Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of mouse early somite-stage embryos.The Journal of veterinary medical science · 2015Article
- The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease.Seminars in cell & developmental biology · 2015Review
- A regulatory network controls nephrocan expression and midgut patterning.Development (Cambridge, England) · 2014Article
- Follow your gut: relaying information from the site of left-right symmetry breaking in the mouse.Genesis (New York, N.Y. : 2000) · 2014Review
- Left Right Patterning, Evolution and Cardiac Development.Journal of cardiovascular development and disease · 2014Article
- Mechanisms of left-right asymmetry and patterning: driver, mediator and responder.F1000prime reports · 2014Review
- Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice.Development (Cambridge, England) · 2013Article
- Cilia, calcium and the basis of left-right asymmetry.BMC biology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
In the mouse, the initial signals that establish left-right (LR) asymmetry are determined in the node by nodal flow. These signals are then transferred to the lateral plate mesoderm (LPM) through cellular and molecular mechanisms that are not well characterized. We hypothesized that endoderm might play a role in this process because it is tightly apposed to the node and covers the outer surface of the embryo, and, just after nodal flow is established, higher Ca(2+) flux has been reported on the left side near the node, most likely in the endoderm cells. Here we studied the role of endoderm cells in the transfer of the LR asymmetry signal by analyzing mouse Sox17 null mutant embryos, which possess endoderm-specific defects. Sox17(-/-) embryos showed no expression or significantly reduced expression of LR asymmetric genes in the left LPM. In Sox17 mutant endoderm, the localization of connexin proteins on the cell membrane was greatly reduced, resulting in defective gap junction formation, which appeared to be caused by incomplete development of organized epithelial structures. Our findings suggest an essential role of endoderm cells in the signal transfer step from the node to the LPM, possibly using gap junction communication to establish the LR axis of the mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.