ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2012
Endotoxin exposure in inner-city schools and homes of children with asthma.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01756391 (Allergens in Inner-City Schools and Childhood Asthma), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Allergens in Inner-City Schools and Childhood Asthma
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Trial
- Endotoxin, food allergen sensitization, and food allergy: A complementary epidemiologic and experimental study.Allergy · 2020Article
- Endotoxin and Der p1 allergen levels in indoor air and settled dust in day-care centers in Tehran, Iran.Journal of environmental health science & engineering · 2019Article
- The Effects of the Environment on Asthma Disease Activity.Immunology and allergy clinics of North America · 2019Review
- Inner-City Asthma in Children.Clinical reviews in allergy & immunology · 2019Review
- School exposure and asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Review
- Ara h2 levels in dust from homes of individuals with peanut allergy and individuals with peanut tolerance.Allergy and asthma proceedings · 2017Article
- Characterization of the bacterial and fungal microbiome in indoor dust and outdoor air samples: a pilot study.Environmental science. Processes & impacts · 2016Article
- Recent advances in environmental controls outside the home setting.Current opinion in allergy and clinical immunology · 2016Review
- Inner-city asthma: special considerations for management.Current opinion in allergy and clinical immunology · 2016Review
- Introducing an environmental assessment and intervention program in inner-city schools.The Journal of allergy and clinical immunology · 2014Review
- Social disadvantage and asthma control in children.Paediatric respiratory reviews · 2014Review
- The indoor environment and inner-city childhood asthma.Asian Pacific journal of allergy and immunology · 2014Review
- Environmental remediation in the treatment of allergy and asthma: latest updates.Current allergy and asthma reports · 2014Review
- Obstructive airway disease in urban populations.Current opinion in pulmonary medicine · 2014Review
- Article
- Diet-induced obesity reprograms the inflammatory response of the murine lung to inhaled endotoxin.Toxicology and applied pharmacology · 2013Article
- The effects of various doses of bacterial lipopolysaccharide on the expression of CD63 and the release of histamine by basophils of atopic and non-atopic patients.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- School Environmental Intervention Programs.The journal of allergy and clinical immunology. In practiceReview
- Beta-2-Adrenergic Receptor Methylation Influences Asthma Phenotype in The School Inner City Asthma Study.Receptors & clinical investigationArticle
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEndotoxins are stimulators of the immune system and, despite their potential to protect against allergy, have been associated with early wheezing and asthma morbidity.
objectiveTo compare inner-city school endotoxin exposure with home endotoxin exposure in children with asthma.
methodsStudents with asthma were recruited from 12 urban elementary schools. Settled and airborne dust samples, linked to enrolled students, were collected from school classrooms, gymnasiums, and cafeterias twice during the academic year. For comparison, settled dust was collected once from the bedrooms of students with asthma.
resultsTwo hundred twenty-nine school settled dust samples and 118 bedroom settled dust samples were collected and analyzed for endotoxin. The median endotoxin concentration for school samples was 13.4 EU/mg (range, 0.7-360.7 EU/mg) and for home samples was 7.0 EU/mg (range = LLOD-843.0 EU/mg). The median concentration within each individual school varied from 6.6 EU/mg to 24.0 EU/mg. One hundred four students with asthma had matched classroom and bedroom endotoxin exposure measurements performed in the same season and demonstrated significantly higher concentrations of endotoxin in the students' classrooms (mean log value, 1.13 vs 0.99, P = .04). The median of the classrooms was 12.5 EU/mg compared with their bedrooms, with a median of 7.0 EU/mg. Within the school environment, no significant difference was seen between the fall and spring samples (mean log value 1.14 vs 1.09; P = .35).
conclusionInner-city children with asthma were exposed to higher concentrations of endotoxin in their classrooms as compared with their bedrooms. Further studies are needed to evaluate school endotoxin exposure as a factor in asthma morbidity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.