ArticleEnvironmental health perspectives2012
Placental mitochondrial DNA content and particulate air pollution during in utero life.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 2 of them syntheses that pooled it.
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Who cites it
121 citing papers in PubMed, 2 syntheses or guidelines pooled it, 243 citations in OpenAlex.
- Prenatal air pollution exposure in relation to the telomere-mitochondrial axis of aging at birth: A systematic review.Environmental research · 2024Pooled it
- Ambient and household PM2.5 pollution and adverse perinatal outcomes: A meta-regression and analysis of attributable global burden for 204 countries and territories.PLoS medicine · 2021Pooled it
- Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations.International journal of environmental research and public health · 2018Trial
- B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial.Proceedings of the National Academy of Sciences of the United States of America · 2017Trial
- Air pollution and adverse birth outcomes: a narrative review of epidemiological and mechanistic findings.Journal of environmental health science & engineering · 2026Review
- Thyroid/parathyroid function and fluoride: role of mitochondrial DNA and SOD genetic variations.Journal of endocrinological investigation · 2026Article
- Prediction of premature rupture of fetal membranes using deep learning in East China.Scientific reports · 2026Article
- Maternal exposure to urban particulate matter induces cardiac developmental toxicity in zebrafish offspring by disrupting mitochondrial homeostasis.Journal of advanced research · 2026Article
- Associations between prenatal exposure to ambient air pollutants and preterm birth in the Atlanta African American maternal-child cohort.Environmental health : a global access science source · 2026Article
- Association of pre-and postnatal mercury exposure with cardiometabolic risk factors in children: the role of the telomere length and telomerase reverse transcriptase polymorphisms.Environment international · 2025Article
- Lithium nickel manganese cobalt oxide particles cause developmental neurotoxicity inEnvironmental science. Advances · 2025Article
- Article
- Impact of short-term air pollution exposure on premature rupture of membranes in the North China Plain, 2015-2021: a multicity case-crossover study.Journal of global health · 2025Article
- The association of prenatal ambient air pollution with placental epigenetic gestational age at birth.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Association of maternal metabolic conditions with mitochondrial DNA copy number in cord blood.Precision nutrition · 2025Article
- Exploring DNA methylation, telomere length, mitochondrial DNA, and immune function in patients with Long-COVID.BMC medicine · 2025Article
- Ambient air pollution and adverse birth outcomes: A review of underlying mechanisms.BJOG : an international journal of obstetrics and gynaecology · 2024Review
- Associations between mitochondrial biomarkers, urban residential exposures and childhood asthma outcomes over 6 months.Environmental research · 2023Article
- Altered cord blood mitochondrial DNA content and prenatal exposure to arsenic metabolites in low-arsenic areas.Research square · 2023Article
- Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study.Environmental health : a global access science source · 2023Article
61 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies emphasize the importance of particulate matter (PM) in the formation of reactive oxygen species and inflammation. We hypothesized that these processes can influence mitochondrial function of the placenta and fetus.
objectiveWe investigated the influence of PM₁₀ exposure during pregnancy on the mitochondrial DNA content (mtDNA content) of the placenta and umbilical cord blood.
methodsDNA was extracted from placental tissue (n = 174) and umbilical cord leukocytes (n = 176). Relative mtDNA copy numbers (i.e., mtDNA content) were determined by real-time polymerase chain reaction. Multiple regression models were used to link mtDNA content and in utero exposure to PM₁₀ over various time windows during pregnancy.
resultsIn multivariate-adjusted analysis, a 10-µg/m³ increase in PM₁₀ exposure during the last month of pregnancy was associated with a 16.1% decrease [95% confidence interval (CI): -25.2, -6.0%, p = 0.003] in placental mtDNA content. The corresponding effect size for average PM₁₀ exposure during the third trimester was 17.4% (95% CI: -31.8, -0.1%, p = 0.05). Furthermore, we found that each doubling in residential distance to major roads was associated with an increase in placental mtDNA content of 4.0% (95% CI: 0.4, 7.8%, p = 0.03). No association was found between cord blood mtDNA content and PM₁₀ exposure.
conclusionsPrenatal PM₁₀ exposure was associated with placental mitochondrial alterations, which may both reflect and intensify oxidative stress production. The potential health consequences of decreased placental mtDNA content in early life must be further elucidated.
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