ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2012
Mental health disorders and long-term opioid use among adolescents and young adults with chronic pain.
Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Relationships among childhood trauma, central sensitization, and opioid-related risks in a community sample of adults with chronic pain on opioids.Pain medicine (Malden, Mass.) · 2026Article
- Association Between Congenital Heart Disease Complexity, Mental Health Conditions and Opioid Use Disorder.JACC. Advances · 2025Article
- Article
- Opioid misuse and mental health in college student populations: A national assessment.Journal of affective disorders · 2024Article
- Preliminary Validation of a General Factor Model of Chronic Overlapping Pain Conditions.The journal of pain · 2024Article
- Chronic Pain and Cannabis Use Frequency, Intensity, and Severity in Young Adults.Substance use & misuse · 2024Article
- A patient-centered nurse-supported primary care-based collaborative care program to treat opioid use disorder and depression: Design and protocol for the MI-CARE randomized controlled trial.Contemporary clinical trials · 2023Article
- Opioid use as a proximal risk factor for suicidal behavior in young adults.Suicide & life-threatening behavior · 2022Article
- National Trends in Suicide Thoughts and Behavior among US Adults with Opioid Use Disorder from 2015 to 2020.Substance use & misuse · 2022Article
- Behavioral Health Risk Factors for Nonmedical Prescription Opioid Use in Adolescence.Pediatrics · 2021Article
- Outpatient prescribing of opioids to adults diagnosed with mental disorders in the United States.Drug and alcohol dependence · 2021Article
- A scoping review of chronic pain in emerging adults.Pain reports · 2021Article
- Identifying Predictive Characteristics of Opioid Medication Use among a Nationally Representative Sample of United States Older Adults with Pain and Comorbid Hypertension or Hypercholesterolemia.Healthcare (Basel, Switzerland) · 2020Article
- Comorbid chronic pain and opioid misuse in youth: Knowns, unknowns, and implications for behavioral treatment.The American psychologist · 2020Review
- Article
- Psychiatric symptoms and recent overdose among people who use heroin or other opioids: Results from a secondary analysis of an intervention study.Addictive behaviors reports · 2019Article
- Article
- Long-term prescription opioid utilization, substance use disorders, and opioid overdoses after adolescent trauma.The journal of trauma and acute care surgery · 2019Article
- Characterizing chronic pain in late adolescence and early adulthood: prescription opioids, marijuana use, obesity, and predictors for greater pain interference.Pain reports · 2018Article
- A Model of the Intersection of Pain and Opioid Misuse in Children and Adolescents.Clinical psychological science : a journal of the Association for Psychological Science · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this study was to examine the association between mental health disorders and subsequent risk for long-term opioid use among adolescents and young adults presenting with common chronic pain complaints (back pain, neck pain, headache, and arthritis/joint pain).
methodsUsing claims data from January 1, 2001 to June 30, 2008, we conducted a longitudinal analysis of opioid use patterns among 13-24-year-old subjects presenting with a new episode of chronic pain. Long-term opioid use was defined as receiving >90 days of opioids within a 6-month period with no gap of >30 days in use of opioids in the 18 months after the first qualifying pain diagnosis. Mental health disorders were identified from claims in the 6 months before the first qualifying pain diagnosis.
resultsFifty-nine thousand seventy-seven youth met criteria for a new episode of chronic pain. Among these youth, 321 (.5%) met criteria for long-term opioid use, and 16,172 (27.4%) had some opioid use. After controlling for demographic and clinical factors, youth with preexisting mental health diagnoses had a 2.4-fold increased risk of subsequently receiving long-term opioids versus no opioids (odds ratio = 2.36, 95% confidence interval = 1.73-3.23) and a 1.8-fold increased likelihood of receiving long-term opioids versus some opioids (odds ratio = 1.83, 95% confidence interval = 1.34-2.50).
conclusionsMental health disorders are associated with increased risk for long-term opioid use among adolescents and emerging young adults. Further study is warranted to examine risks and benefits of long-term opioid use in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.