ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2012
In vivo multiphoton microscopy technique to reveal the physiology of the mouse placenta.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 34 citations in OpenAlex.
- Deciphering decidual leukocyte traffic with serial intravascular staining.Frontiers in immunology · 2023Article
- Live-cell imaging of microglial interactions with radial glia in transgenic embryonic mouse brains using slice culture.STAR protocols · 2021Article
- A novel murine model for assessing fetal and birth outcomes following transgestational maternal malaria infection.Scientific reports · 2019Article
- Deep insights: intravital imaging with two-photon microscopy.Pflugers Archiv : European journal of physiology · 2016Review
- Major mouse placental compartments revealed by diffusion-weighted MRI, contrast-enhanced MRI, and fluorescence imaging.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Ex vivo perfusion of mid-to-late-gestation mouse placenta for maternal-fetal interaction studies during pregnancy.Nature protocols · 2013Article
- Magnetic resonance imaging detects placental hypoxia and acidosis in mouse models of perturbed pregnancies.PloS one · 2013Article
- Intravital placenta imaging reveals microcirculatory dynamics impact on sequestration and phagocytosis of Plasmodium-infected erythrocytes.PLoS pathogens · 2013Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
problemPregnancy is a challenge to the maternal immune system as it must defend the body against pathogens while at the same time develop immune tolerance against the fetus growing inside the uterus. Despite ex vivo techniques being used to understand these processes, in vivo techniques are missing. METHOD OF STUDY: To directly study these phenomena, we have developed a new microscope stage and surgical procedures for use in two-photon microscopy, for in vivo observation of the mouse placenta.
resultsThese tools and surgical procedures demonstrate fetal and maternal blood flow inside the labyrinth zone of the placenta, as well as its three dimensional structure. It was also useful to identify Plasmodium chabaudi-infected red blood cells inside this labyrinth zone.
conclusionWe believe this technique will represent an important contribution for expanding the available knowledge concerning cell dynamics and interactions at the fetal-maternal interface.
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Registered trials
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