ArticleBMC microbiology2012
Multi-locus variable number tandem repeat analysis of 7th pandemic Vibrio cholerae.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 37 citations in OpenAlex.
- Molecular characterization ofJournal of medical microbiology · 2021Article
- A Vibrio cholerae Core Genome Multilocus Sequence Typing Scheme To Facilitate the Epidemiological Study of Cholera.Journal of bacteriology · 2020Article
- Epidemiological and molecular forensics of cholera recurrence in Haiti.Scientific reports · 2019Article
- Evaluation of Whole-Genome Sequencing for Identification and Typing of Vibrio cholerae.Journal of clinical microbiology · 2018Article
- Cholera Epidemic in South Sudan and Uganda and Need for International Collaboration in Cholera Control.Emerging infectious diseases · 2018Article
- Dynamics of cholera epidemics from Benin to Mauritania.PLoS neglected tropical diseases · 2018Article
- Minimal genetic change in Vibrio cholerae in Mozambique over time: Multilocus variable number tandem repeat analysis and whole genome sequencing.PLoS neglected tropical diseases · 2017Article
- Characterization of Vibrio cholerae Strains Isolated from the Nigerian Cholera Outbreak in 2010.Journal of clinical microbiology · 2016Article
- Evolution of Variable Number Tandem Repeats and Its Relationship with Genomic Diversity inFrontiers in microbiology · 2016Article
- Evaluation in Cameroon of a Novel, Simplified Methodology to Assist Molecular Microbiological Analysis of V. cholerae in Resource-Limited Settings.PLoS neglected tropical diseases · 2016Article
- Article
- Molecular tools in understanding the evolution of Vibrio cholerae.Frontiers in microbiology · 2015Review
- Relationship between Distinct African Cholera Epidemics Revealed via MLVA Haplotyping of 337 Vibrio cholerae Isolates.PLoS neglected tropical diseases · 2015Article
- The population structure of Vibrio cholerae from the Chandigarh Region of Northern India.PLoS neglected tropical diseases · 2014Article
- Vaccines against human diarrheal pathogens: current status and perspectives.Human vaccines & immunotherapeutics · 2014Review
- Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen.Current topics in microbiology and immunology · 2014Review
- Genetic variation of Vibrio cholerae during outbreaks, Bangladesh, 2010-2011.Emerging infectious diseases · 2014Article
- Diversity of Salmonella enterica serovar Typhi strains collected from india using variable number tandem repeat (VNTR)-PCR analysis.Molecular diagnosis & therapy · 2013Article
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4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeven pandemics of cholera have been recorded since 1817, with the current and ongoing pandemic affecting almost every continent. Cholera remains endemic in developing countries and is still a significant public health issue. In this study we use multilocus variable number of tandem repeats (VNTRs) analysis (MLVA) to discriminate between isolates of the 7th pandemic clone of Vibrio cholerae.
resultsMLVA of six VNTRs selected from previously published data distinguished 66 V. cholerae isolates collected between 1961-1999 into 60 unique MLVA profiles. Only 4 MLVA profiles consisted of more than 2 isolates. The discriminatory power was 0.995. Phylogenetic analysis showed that, except for the closely related profiles, the relationships derived from MLVA profiles were in conflict with that inferred from Single Nucleotide Polymorphism (SNP) typing. The six SNP groups share consensus VNTR patterns and two SNP groups contained isolates which differed by only one VNTR locus.
conclusionsMLVA is highly discriminatory in differentiating 7th pandemic V. cholerae isolates and MLVA data was most useful in resolving the genetic relationships among isolates within groups previously defined by SNPs. Thus MLVA is best used in conjunction with SNP typing in order to best determine the evolutionary relationships among the 7th pandemic V. cholerae isolates and for longer term epidemiological typing.
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