ArticleLangmuir : the ACS journal of surfaces and colloids2012
Bifunctional Janus microparticles with spatially segregated proteins.
Article in Langmuir : the ACS journal of surfaces and colloids, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- Bottom-Up Construction of the Interaction between Janus Particles.The journal of physical chemistry. B · 2023Article
- Janus particles and motors: unrivaled devices for mastering (bio)sensing.Mikrochimica acta · 2021Review
- Bifunctional Janus Particles as Multivalent Synthetic Nanoparticle Antibodies (SNAbs) for Selective Depletion of Target Cells.Nano letters · 2021Article
- Fc microparticles can modulate the physical extent and magnitude of complement activity.Biomaterials science · 2017Article
- Interrogating Cellular Functions with Designer Janus Particles.Chemistry of materials : a publication of the American Chemical Society · 2017Article
- A Liquid-Handling Robot for Automated Attachment of Biomolecules to Microbeads.Journal of laboratory automation · 2016Article
- Force and torque on spherical particles in micro-channel flows using computational fluid dynamics.Royal Society open science · 2016Article
- Janus particles for biological imaging and sensing.The Analyst · 2016Review
- Chemically orthogonal three-patch microparticles.Angewandte Chemie (International ed. in English) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We present a fabrication process to create bifunctional microparticles displaying two distinct proteins that are spatially segregated onto the surface hemispheres. Silica and polystyrene microparticles with 2.0, 4.1, and 4.7 μm diameters are processed with metal deposition to form two chemically distinct and segregated hemispheres. The surface of each hemisphere is then separately derivatized with biological proteins using different chemical conjugation strategies. These bifunctional Janus particles possess biologically relevant, native conformation proteins attached to a biologically unreactive and safe substrate. They also display high densities of each type of protein which may enable a range of capabilities that monofunctional particles cannot, such as improved targeting of drugs and bioimaging agents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.