ArticleTransfusion2013
Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B.
Article in Transfusion, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Immune-mediated platelet refractoriness: Mechanisms, diagnostics, and therapeutic breakthroughs.Transfusion medicine (Oxford, England) · 2026Review
- ABO blood group, ABO mismatched transfusions and leukoreduction of transfusions in hemostatic resuscitation studies.Frontiers in bioengineering and biotechnology · 2024Article
- Associations between ABO non-identical platelet transfusions and patient outcomes-A multicenter retrospective analysis.Transfusion · 2023Article
- The Evolution of Blood Product Use in Trauma Resuscitation: Change Has Come.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Article
- Review
- The HIV protease inhibitor, ritonavir, dysregulates human platelet function in vitro.Thrombosis research · 2018Article
- Resveratrol preserves the function of human platelets stored for transfusion.British journal of haematology · 2016Article
- ABO matching of platelet transfusions - "Start Making Sense". "As we get older, and stop making sense…" - The Talking Heads (1984).Blood transfusion = Trasfusione del sangue · 2015Article
- Transfusion of ABO non-identical platelets does not influence the clinical outcome of patients undergoing autologous haematopoietic stem cell transplantation.Blood transfusion = Trasfusione del sangue · 2015Article
- Platelet transfusion - the new immunology of an old therapy.Frontiers in immunology · 2015Review
- ABO mismatched platelet transfusions in trauma patients.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014Article
- Platelet transfusion - the art and science of compromise.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2013Article
- Current trends in platelet transfusions practice: The role of ABO-RhD and human leukocyte antigen incompatibility.Asian journal of transfusion scienceReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundABO-mismatched platelets (PLTs) are commonly transfused despite reported complications. We hypothesized that because PLTs possess A and B antigens on their surface, ABO-mismatched transfused or recipient PLTs could become activated and/or dysfunctional after exposure to anti-A or -B in the transfused or recipient plasma. We present here in vitro modeling data on the functional effects of exposure of PLTs to ABO antibodies. STUDY DESIGN AND
methodsPLT functions of normal PLTs of all ABO types were assessed before and after incubation with normal saline, ABO-identical plasma samples, or O plasma samples with varying titers of anti-A and anti-B (anti-A/B). Assays used for this assessment include PLT aggregation, clot kinetics, thrombin generation, PLT cytoskeletal function, and mediator release.
resultsExposure of antigen-bearing PLTs to O plasma with moderate to high titers of anti-A/B significantly inhibits aggregation, prolongs PFA-100 epinephrine closure time, disrupts clot formation kinetics, accelerates thrombin generation, reduces total thrombin production, alters PLT cytoskeletal function, and influences proinflammatory and prothrombotic mediator release.
conclusionsOur findings demonstrate a wide range of effects that anti-A/B have on PLT function, clot formation, thrombin generation, PLT cytoskeletal function, and mediator release. These data provide potential explanations for clinical observations of increased red blood cell utilization in trauma and surgical patients receiving ABO-nonidentical blood products. Impaired hemostasis caused by anti-A/B interacting with A and B antigens on PLTs, soluble proteins, and perhaps even endothelial cells is a potential contributing factor to hemorrhage in patients receiving larger volumes of ABO-nonidentical transfusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.