ArticlePloS one2012
Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Mechanisms and treatments of lymphedema.Frontiers in immunology · 2026Review
- IL-19 Is a Novel Lymphangiocrine Factor Inducing Lymphangiogenesis and Lymphatic Junctional Regulation.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- CXADR: From an Essential Structural Component to a Vital Signaling Mediator in Spermatogenesis.International journal of molecular sciences · 2023Review
- Human Coxsackie- and adenovirus receptor is a putative target of neutrophil elastase-mediated shedding.Molecular biology reports · 2022Article
- The Coxsackievirus and Adenovirus Receptor Has a Short Half-Life in Epithelial Cells.Pathogens (Basel, Switzerland) · 2022Article
- Fetal nuchal edema and developmental anomalies caused by gene mutations in mice.Frontiers in cell and developmental biology · 2022Review
- The cell surface hyaluronidase TMEM2 is essential for systemic hyaluronan catabolism and turnover.The Journal of biological chemistry · 2021Article
- Coxsackievirus and Adenovirus Receptor (CXADR): Recent Findings and Its Role and Regulation in Spermatogenesis.Advances in experimental medicine and biology · 2021Review
- Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin.Frontiers in physiology · 2020Review
- Generation and evaluation of a chimeric antibody against coxsackievirus and adenovirus receptor for cancer therapy.Cancer science · 2019Article
- Establishment and maintenance of blood-lymph separation.Cellular and molecular life sciences : CMLS · 2019Review
- Secondary Placental Defects inFrontiers in physiology · 2019Article
- A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo.Scientific reports · 2017Article
- TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers.Scientific reports · 2016Article
- A Closer Look at Schlemm's Canal Cell Physiology: Implications for Biomimetics.Journal of functional biomaterials · 2015Review
- Primary and secondary lymphatic valve development: molecular, functional and mechanical insights.Microvascular research · 2014Review
- Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor.Journal of virology · 2014Article
- Development of the mammalian lymphatic vasculature.The Journal of clinical investigation · 2014Review
- JAM-related proteins in mucosal homeostasis and inflammation.Seminars in immunopathology · 2014Review
- Comparative and developmental anatomy of cardiac lymphatics.TheScientificWorldJournal · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coxsackie- and adenovirus receptor (CAR) is a cell adhesion molecule predominantly associated with epithelial tight junctions in adult tissues. CAR is also expressed in cardiomyocytes and essential for heart development up to embryonic day 11.5, but not thereafter. CAR is not expressed in vascular endothelial cells but was recently detected in neonatal lymphatic vessels, suggesting that CAR could play a role in the development of the lymphatic system. To address this, we generated mice carrying a conditional deletion of the CAR gene (Cxadr) and knocked out CAR in the mouse embryo at different time points during post-cardiac development. Deletion of Cxadr from E12.5, but not from E13.5, resulted in subcutaneous edema, hemorrhage and embryonic death. Subcutaneous lymphatic vessels were dilated and structurally abnormal with gaps and holes present at lymphatic endothelial cell-cell junctions. Furthermore, lymphatic vessels were filled with erythrocytes showing a defect in the separation between the blood and lymphatic systems. Regionally, erythrocytes leaked out into the interstitium from leaky lymphatic vessels explaining the hemorrhage detected in CAR-deficient mouse embryos. The results show that CAR plays an essential role in development of the lymphatic vasculature in the mouse embryo by promoting appropriate formation of lymphatic endothelial cell-cell junctions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.