ArticlePloS one2012
A low concentration of ethanol impairs learning but not motor and sensory behavior in Drosophila larvae.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- The Effects of Ethanol and Acetic acid on Behaviour of Extranidal Workers of the Narrow-Headed AntAnimals : an open access journal from MDPI · 2023Article
- Article
- Continuous, long-term crawling behavior characterized by a robotic transport system.bioRxiv : the preprint server for biology · 2023Article
- The function of ethanol in olfactory associative behaviors in Drosophila melanogaster larvae.PloS one · 2023Article
- Ethanol-guided behavior in Drosophila larvae.Scientific reports · 2021Article
- Transcriptional Correlates of Chronic Alcohol Neuroadaptation inFrontiers in behavioral neuroscience · 2021Article
- Ethanol stimulates the in vivo axonal movement of neuropeptide dense-core vesicles in Drosophila motor neurons.Journal of neurochemistry · 2018Article
- Chemosensory apparatus of Drosophila larvae.Bioinformation · 2015Article
- Developmental age strengthens barriers to ethanol accumulation in zebrafish.Alcohol (Fayetteville, N.Y.) · 2014Article
- Is alcoholism learned? Insights from the fruit fly.Current opinion in neurobiology · 2013Article
- A new treatment for cognitive disorders related to in utero exposure to alcohol.Neural regeneration research · 2013Article
- Drosophila larvae as a model to study physiological alcohol dependence.Communicative & integrative biology · 2013Article
Corrections and comments
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Authors and funding
26 authors at 1 institution in 1 country.
Funding
Abstract
Drosophila melanogaster has proven to be a useful model system for the genetic analysis of ethanol-associated behaviors. However, past studies have focused on the response of the adult fly to large, and often sedating, doses of ethanol. The pharmacological effects of low and moderate quantities of ethanol have remained understudied. In this study, we tested the acute effects of low doses of ethanol (∼7 mM internal concentration) on Drosophila larvae. While ethanol did not affect locomotion or the response to an odorant, we observed that ethanol impaired associative olfactory learning when the heat shock unconditioned stimulus (US) intensity was low but not when the heat shock US intensity was high. We determined that the reduction in learning at low US intensity was not a result of ethanol anesthesia since ethanol-treated larvae responded to the heat shock in the same manner as untreated animals. Instead, low doses of ethanol likely impair the neuronal plasticity that underlies olfactory associative learning. This impairment in learning was reversible indicating that exposure to low doses of ethanol does not leave any long lasting behavioral or physiological effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.