ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Plasticity of recurrent inhibition in the Drosophila antennal lobe.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 66 citations in OpenAlex.
- Selective lifelong suppression of an odor processing channel in response to critical period experience.eLife · 2026Article
- Manifold learning for olfactory habituation to strongly fluctuating backgrounds.bioRxiv : the preprint server for biology · 2025Article
- Plasticity in inhibitory networks improves pattern separation in early olfactory processing.Communications biology · 2025Article
- Nonlinear high-activity neuronal excitation enhances odor discrimination.Current biology : CB · 2025Article
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- Glia control experience-dependent plasticity in an olfactory critical period.bioRxiv : the preprint server for biology · 2024Article
- Normative and mechanistic model of an adaptive circuit for efficient encoding and feature extraction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Social experience and pheromone receptor activity reprogram gene expression in sensory neurons.G3 (Bethesda, Md.) · 2023Article
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- Identification of a GABAergic neuroblast lineage modulating sweet and bitter taste sensitivity.Current biology : CB · 2022Article
- Olfactory responses ofeLife · 2022Article
- Forgetting as a form of adaptive engram cell plasticity.Nature reviews. Neuroscience · 2022Review
- Article
- GPCR voltage dependence controls neuronal plasticity and behavior.Nature communications · 2021Article
- Adaptive temporal processing of odor stimuli.Cell and tissue research · 2021Review
- Glomerulus-Selective Regulation of a Critical Period for Interneuron Plasticity in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Muscarinic Modulation of Antennal Lobe GABAergic Local Neurons Shapes Odor Coding and Behavior.Cell reports · 2019Article
- Individual differences in learning and biogenic amine levels influence the behavioural division between foraging honeybee scouts and recruits.The Journal of animal ecology · 2019Article
- Temporally specific engagement of distinct neuronal circuits regulating olfactory habituation ineLife · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent inhibition, wherein excitatory principal neurons stimulate inhibitory interneurons that feedback on the same principal cells, occurs ubiquitously in the brain. However, the regulation and function of recurrent inhibition are poorly understood in terms of the contributing interneuron subtypes as well as their effect on neural and cognitive outputs. In the Drosophila olfactory system, odorants activate olfactory sensory neurons (OSNs), which stimulate projection neurons (PNs) in the antennal lobe. Both OSNs and PNs activate local inhibitory neurons (LNs) that provide either feedforward or recurrent/feedback inhibition in the lobe. During olfactory habituation, prior exposure to an odorant selectively decreases the animal's subsequent response to the odorant. We show here that habituation occurs in response to feedback from PNs. Output from PNs is necessary for olfactory habituation and, in the absence of odorant, direct PN activation is sufficient to induce the odorant-selective behavioral attenuation characteristic of olfactory habituation. PN-induced habituation occludes further odor-induced habituation and similarly requires GABA(A)Rs and NMDARs in PNs, as well as VGLUT and cAMP signaling in the multiglomerular inhibitory local interneurons (LN1) type of LN. Thus, PN output is monitored by an LN subtype whose resultant plasticity underlies behavioral habituation. We propose that recurrent inhibitory motifs common in neural circuits may similarly underlie habituation to other complex stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.