ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
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- Development and Evolution of Thalamocortical Connectivity.Cold Spring Harbor perspectives in biology · 2024Review
- Evaluation of advances in cortical development using model systems.Developmental neurobiology · 2022Review
- The topography of corticopontine projections is controlled by postmitotic expression of the area-mapping gene Nr2f1.Development (Cambridge, England) · 2022Article
- Modelling the emergence of whisker barrels.eLife · 2020Article
- How the Barrel Cortex Became a Working Model for Developmental Plasticity: A Historical Perspective.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Limit cycle dynamics can guide the evolution of gene regulatory networks towards point attractors.Scientific reports · 2019Article
- A model of neocortical area patterning in the lissencephalic mouse may hold for larger gyrencephalic brains.The Journal of comparative neurology · 2019Article
- Precision in the development of neocortical architecture: From progenitors to cortical networks.Progress in neurobiology · 2019Review
- Development of tactile sensory circuits in the CNS.Current opinion in neurobiology · 2018Review
- Developmental interactions between thalamus and cortex: a true love reciprocal story.Current opinion in neurobiology · 2018Review
- The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.Stem cell reports · 2018Article
- DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Behavioral Consequences of a Bifacial Map in the Mouse Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The neuroanatomy of autism - a developmental perspective.Journal of anatomy · 2017Review
- From Savannas to Settlements: Exploring Cognitive Foundations for the Design of Urban Spaces.Frontiers in psychology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The concept of an "organizer" is basic to embryology. An organizer is a portion of the embryo producing signals that lead to the creation of a patterned mature structure from an embryonic primordium. Fibroblast growth factor 8 (FGF8) is a morphogen that disperses from a rostromedial source in the neocortical primordium (NP), forms a rostral-to-caudal (R/C) gradient, and regulates embryonic and neonatal R/C patterns of gene expression in neocortex. Whether FGF8 also has organizer activity that generates the postnatal neocortical area map is uncertain. To test this possibility, new sources of FGF8 were introduced into the mouse NP with in utero microelectroporation at embryonic day 10.5, close to the estimated peak of area patterning. Results differed depending on the position of ectopic FGF8. Ectopic FGF8 in the caudalmost NP could duplicate somatosensory cortex (S1) and primary visual cortex (V1). FGF8 delivered to the midlateral NP generated a sulcus separating rostral and caudal portions of the NP, in effect creating duplicate NPs. In the caudal NP, ectopic FGF8 induced a second, inclusive area map, containing frontal cortex, S1, V1, and primary auditory areas. Moreover, duplicate S1 showed plasticity to sensory deprivation, and duplicate V1 responded to visual stimuli. Our findings implicate FGF8 as an organizer signal, and its source in the rostromedial telencephalon as an organizer of the neocortical area map.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.