ArticleJournal of the National Cancer Institute2012
Perinatal and family risk factors for non-Hodgkin lymphoma in early life: a Swedish national cohort study.
Article in Journal of the National Cancer Institute, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cancer risk in children and young adults born preterm: A systematic review and meta-analysis.PloS one · 2019Pooled it
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- B-NHL Cases in a Tertiary Pediatric Hematology-Oncology Department: A 20-Year Retrospective Cohort Study.Life (Basel, Switzerland) · 2024Article
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- Neurocutaneous Syndromes, Perinatal Factors, and the Risk of Childhood Cancer in Sweden.JAMA network open · 2023Article
- Association between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study.Scientific reports · 2023Article
- The role of parental and perinatal characteristics on Langerhans cell histiocytosis: characterizing increased risk among Hispanics.Annals of epidemiology · 2018Article
- Geographical Correlations between Indoor Radon Concentration and Risks of Lung Cancer, Non-Hodgkin's Lymphoma, and Leukemia during 1999-2008 in Korea.International journal of environmental research and public health · 2017Article
- Familial risk of non-Hodgkin lymphoma by sex, relationship, age at diagnosis and histology: a joint study from five Nordic countries.Leukemia · 2016Article
- Perinatal risk factors for acute myeloid leukemia.European journal of epidemiology · 2015Article
- Residential Radon Exposure and Incidence of Childhood Lymphoma in Texas, 1995-2011.International journal of environmental research and public health · 2015Article
- Fetal growth and subsequent maternal risk of colorectal cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Parental Age at Birth and Risk of Hematological Malignancies in Older Adults.American journal of epidemiology · 2015Article
- Perinatal and familial risk factors for acute lymphoblastic leukemia in a Swedish national cohort.Cancer · 2015Article
- Perinatal and familial risk factors for brain tumors in childhood through young adulthood.Cancer research · 2015Article
- Cancer incidence in Canada: trends and projections (1983-2032).Health promotion and chronic disease prevention in Canada : research, policy and practice · 2015Review
- Season of birth and risk of Hodgkin and non-Hodgkin lymphoma.International journal of cancer · 2014Article
- Fetal growth and childhood cancer: a population-based study.Pediatrics · 2013Article
- Non-Hodgkin lymphoma in early life.Journal of the National Cancer Institute · 2012Article
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Abstract
backgroundThe incidence of non-Hodgkin lymphoma (NHL) in early life has increased in recent decades, but the relevant risk factors remain largely unknown. We examined perinatal and family risk factors for NHL in childhood through young adulthood.
methodsWe conducted a national cohort study of 3 571 574 individuals born in Sweden in 1973-2008 who were followed for incidence of NHL through 2009 (ages 0-37 years). Detailed information on perinatal and family characteristics and NHL diagnoses were obtained from national birth and cancer registries. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between perinatal and family variables and NHL; P values are from two-sided tests.
resultsThere were 936 NHL case patients identified in 66.3 million person-years of follow-up. Independent risk factors for NHL included family history of NHL in either a sibling (adjusted HR = 9.84; 95% CI = 2.46 to 39.41; P = .001) or parent (adjusted HR = 2.36; 95% CI = 1.27 to 4.38; P = .007); high fetal growth (for ≥ 2 SDs relative to 0 to <1 SD from the mean: adjusted HR = 1.64; 95% CI = 1.19 to 2.25; P = .002); older maternal age (adjusted HR for each 5-year increment = 1.11; 95% CI = 1.04 to 1.19; P (trend) = .004); low birth order (adjusted HR for each increment of one birth = 0.91; 95% CI = 0.84 to 0.99; P (trend) = .02); and male sex (adjusted HR = 1.58; 95% CI = 1.38 to 1.80; P < .001). Male sex was associated with onset of NHL before 15 years of age but not with later-onset NHL, whereas the other risk factors did not vary by age at diagnosis. No association was found between gestational age at birth, twinning, paternal age, or parental education and NHL.
conclusionIn this large national cohort study, family history of NHL, high fetal growth, older maternal age, low birth order, and male sex were independent risk factors for NHL in early life.
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