ArticleThe Journal of nutrition2012
Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults.
Article in The Journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 115 citations in OpenAlex.
- Trial
- B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial.The journal of prevention of Alzheimer's disease · 2017Trial
- Vitamin B6 produced by gut microbiome regulates host behavioral phenotypes through dopaminergic metabolism.Gut microbes · 2026Article
- The Prevalence of Nutritional Imbalances in the US Population Over Time: Biomarker Data from the Cross-Sectional National Health and Nutrition Examination Survey (NHANES 1999-2000 through August 2021-August 2023).Current developments in nutrition · 2026Article
- Dietary Supplement Use Explains More Variance in Nutritional Biomarker Concentrations than 24-Hour Dietary Intake from Food Only: Evidence from a Cross-Sectional Survey of the United States Population (NHANES 2003-2006).Current developments in nutrition · 2026Article
- Plasma vitamin profiles and their associations with metabolic health and mental wellbeing in midlife Asian women.Scientific reports · 2026Article
- Ceramides and neuroinflammation as immunometabolic drivers and biomarkers of major depressive disorder, treatment-resistant depression, and suicidal vulnerability.Frontiers in pharmacology · 2026Review
- Exploring the link between water-soluble vitamins and aging-associated immune system status.Frontiers in immunology · 2026Review
- Folate in autism neurodevelopment.Frontiers in nutrition · 2026Review
- Micronutrient Biomarker Selection and Assay Methods and Performance in Double-Blind, Randomized, Controlled Micronutrient Dose Response (MiNDR) Trials among Women of Reproductive Age and Pregnant Women in Rural Bangladesh.Current developments in nutrition · 2025Article
- Vitamins, Vascular Health and Disease.Nutrients · 2025Review
- Low-Carbohydrate Diet Patterns That Favor High-Quality Carbohydrates Are Associated with Beneficial Long-Term Changes in Biomarkers of Inflammation and Oxidative Stress in the Framingham Offspring Cohort.Current developments in nutrition · 2025Article
- Genetic evidence of the causal relationship between serum micronutrients and Graves' disease: A Mendelian randomization and cross-sectional observational study.Asia Pacific journal of clinical nutrition · 2025Observational
- Urinary 4-pyridoxic acid as a non-invasive biomarker for evaluating osteoarthritis severity: findings from the ROAD study.Aging clinical and experimental research · 2025Article
- Vitamin B6 status, type 2 diabetes mellitus, and periodontitis: evidence from the NHANES database 2009-2010.BMC oral health · 2025Article
- FDA-approved drug repurposing screen identifies inhibitors of SARS-CoV-2 pseudovirus entry.Frontiers in pharmacology · 2025Article
- Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.Brain and behavior · 2024Article
- Serum Pyridoxal 5'-Phosphate and Pyridoxic Acid Ratio Index with Prognosis of Colorectal Cancer: A Prospective Cohort Study.Nutrients · 2024Article
- Assessing and Monitoring Nutrition Security in the United States: A Narrative Review of Current Measures and Instruments.Current nutrition reports · 2024Review
- Vitamin B6 ameliorates acute pancreatitis by suppressing the caspase3 signaling pathway.BMC gastroenterology · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Low vitamin B-6 status, based on plasma concentrations of pyridoxal-5-phosphate (PLP), has been identified in inflammatory diseases, including cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and diabetes. Our objective was to examine the association between plasma PLP and multiple markers of inflammation in a community-based cohort [n = 2229 participants (55% women, mean age 61 ± 9 y)]. We created an overall inflammation score (IS) as the sum of standardized values of 13 individual inflammatory markers. Multivariable-adjusted regression analysis was used to assess the associations between the IS and plasma PLP. Geometric mean plasma PLP concentrations were lower in the highest tertile category of IS relative to the lowest (61 vs. 80 nmol/L; P-trend < 0.0001). Similarly, the prevalence of PLP insufficiency was significantly higher for participants in the highest compared with the lowest tertiles for IS categories. These relationships persisted after accounting for vitamin B-6 intake. Also, there were significant inverse relationships between plasma PLP and 4 IS based on functionally related markers, including acute phase reactants, cytokines, adhesion molecules, and oxidative stress. In addition, secondary analyses revealed that many of the individual inflammatory markers were inversely associated with plasma PLP after adjusting for plasma C-reactive protein concentration. This study, in combination with past findings, further supports our hypothesis that inflammation is associated with a functional deficiency of vitamin B-6. We discuss 2 possible roles for PLP in the inflammatory process, including tryptophan metabolism and serine hydroxymethyltransferase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.