ArticleJournal of cell communication and signaling2012
Molecular mechanisms underlying the fetal programming of adult disease.
Article in Journal of cell communication and signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Effect of Perinatal and Maternal Factors on Blood Pressure and Adiposity at Age 3.Journal of clinical hypertension (Greenwich, Conn.) · 2026Observational
- Fetal Cardiac Remodeling and Subclinical Myocardial Dysfunction in Pregnancies Complicated by Placenta Accreta Spectrum: A Prospective Echocardiographic Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Steroid Metabolome Analysis in Dichorionic Diamniotic Twin Pregnancy.International journal of molecular sciences · 2024Article
- Cardiovascular effect of preeclampsia upon offspring development: Are (Pro) renin-renin receptor ((P)RR) and gender related?Iranian journal of basic medical sciences · 2024Article
- Pathomechanisms of Prenatally Programmed Adult Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- DietaryAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Untargeted metabolomics reveals sex-specific differences in lipid metabolism of adult rats exposed to dexamethasone in utero.Scientific reports · 2021Article
- Inhibition of DNA methylation in newborns reprograms ischemia-sensitive biomarkers resulting in development of a heart ischemia-sensitive phenotype late in life.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
- Decreased Lymphangiogenic Activities and Genes Expression of Cord Blood Lymphatic Endothelial Progenitor Cells (VEGFR3International journal of molecular sciences · 2021Article
- The Role of Early Programming and Early Nutrition on the Development and Progression of Celiac Disease: A Review.Nutrients · 2020Review
- Maternal and gestational influences on childhood blood pressure.Pediatric nephrology (Berlin, Germany) · 2020Article
- Mechanism of Placenta Damage in Gestational Diabetes Mellitus by Investigating TXNIP of Patient Samples and Gene Functional Research in Cell Line.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019Article
- ASAS-SSR Triennnial Reproduction Symposium: Looking Back and Moving Forward-How Reproductive Physiology has Evolved: Fetal origins of impaired muscle growth and metabolic dysfunction: Lessons from the heat-stressed pregnant ewe.Journal of animal science · 2018Review
- A high nutrient dense diet alters hypothalamic gene expressions to influence energy intake in pigs born with low birth weight.Scientific reports · 2018Article
- Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease.Journal of nutrition and metabolism · 2018Review
- Article
- Long-term consequences of disrupting adenosine signaling during embryonic development.Molecular aspects of medicine · 2017Review
- In Utero Caffeine Exposure Induces Transgenerational Effects on the Adult Heart.Scientific reports · 2016Article
- Recent clinical and translational advances in pediatric hypertension.Hypertension (Dallas, Tex. : 1979) · 2015Review
- Longitudinal changes in infant body composition: association with childhood obesity.Pediatric obesity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse events in utero can be critical in determining quality of life and overall health. It is estimated that up to 50 % of metabolic syndrome diseases can be linked to an adverse fetal environment. However, the mechanisms linking impaired fetal development to these adult diseases remain elusive. This review uncovers some of the molecular mechanisms underlying how normal physiology may be impaired in fetal and postnatal life due to maternal insults in pregnancy. By understanding the mechanisms, which include epigenetic, transcriptional, endoplasmic reticulum (ER) stress, and reactive oxygen species (ROS), we also highlight how intervention in fetal and neonatal life may be able to prevent these diseases long-term.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.