ArticleNeuroscience bulletin2012
Tetrahydropalmatine protects against methamphetamine-induced spatial learning and memory impairment in mice.
Article in Neuroscience bulletin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Gut Microbiota Taxon-Dependent Transformation of Microglial M1/M2 Phenotypes Underlying Mechanisms of Spatial Learning and Memory Impairment after Chronic Methamphetamine Exposure.Microbiology spectrum · 2023Article
- Corydalis decumbens Can Exert Analgesic Effects in a Mouse Neuropathic Pain Model by Modulating MAPK Signaling.Computational and mathematical methods in medicine · 2022Article
- A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine.Frontiers in pharmacology · 2022Review
- Attenuative Effects of Fluoxetine andMolecules (Basel, Switzerland) · 2021Article
- Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review.Frontiers in pharmacology · 2021Review
- Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats.Frontiers in behavioral neuroscience · 2021Article
- Methamphetamine-associated cognitive decline is attenuated by neutralizing IL-1 signaling.Brain, behavior, and immunity · 2019Article
- The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice.Neurotoxicity research · 2019Article
- Cognition and Related Neural Findings on Methamphetamine Use Disorder: Insights and Treatment Implications From Schizophrenia Research.Frontiers in psychiatry · 2019Review
- Cinnamaldehyde improves methamphetamine-induced spatial learning and memory deficits and restores ERK signaling in the rat prefrontal cortex.Iranian journal of basic medical sciences · 2018Article
- Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Model of Alzheimer's Disease.Neuroscience bulletin · 2018Article
- Tetrahydropalmatine Prevents High-Fat Diet-Induced Hyperlipidemia in Golden Hamsters (Mesocricetus Auratus).Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension.Free radical biology & medicine · 2016Article
- Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects.Progress in molecular biology and translational science · 2016Review
- Cognitive deficits associated with combined HIV gp120 expression and chronic methamphetamine exposure in mice.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015Article
- Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species.Free radical biology & medicine · 2014Article
- Regulation of NADPH oxidase 5 by protein kinase C isoforms.PloS one · 2014Article
- Methamphetamine and Parkinson's disease.Parkinson's disease · 2013Article
- Role of natural products in mitigation of toxic effects of methamphetamine: A review ofAvicenna journal of phytomedicineReview
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe purpose of this study was to investigate the effect of methamphetamine (MA) on spatial learning and memory and the role of tetrahydropalmatine (THP) in MA-induced changes in these phenomena in mice.
methodsMale C57BL/6 mice were randomly divided into eight groups, according to different doses of MA, different doses of THP, treatment with both MA and THP, and saline controls. Spatial learning and memory were assessed using the Morris water maze. Western blot was used to detect the expression of extracellular signal-regulated protein kinase (ERK) in the mouse prefrontal cortex (PFC) and hippocampus.
resultsRepeated MA treatment significantly increased the escape latency in the learning phase and decreased the number of platform site crossings in the memory-test phase. ERK1/2 expression was decreased in the PFC but not in the hippocampus of the MA-treated mice. Repeated THP treatment alone did not affect the escape latency, the number of platform site crossings or the total ERK1/2 expression in the brain. Statistically significantly shorter escape latencies and more platform site crossings occurred in MA+THP-treated mice than in MA-treated mice.
conclusionRepeated MA administration impairs spatial learning and memory in mice, and its co-administration with THP prevents this impairment, which is probably attributable to changed ERK1/2 expression in the PFC. This study contributes to uncovering the mechanism underlying MA abuse, and to exploring potential therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.