ArticleStem cell reviews and reports2012
Human periosteum-derived stem cells for tissue engineering applications: the role of VEGF.
Article in Stem cell reviews and reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Biomimicking design of artificial periosteum for promoting bone healing.Journal of orthopaedic translation · 2022Review
- Assessment of the Bone Healing Process Mediated by Periosteum-Derived Mesenchymal Stem Cells' Secretome and a Xenogenic Bioceramic-An In Vivo Study in the Rabbit Critical Size Calvarial Defect Model.Materials (Basel, Switzerland) · 2021Article
- MicroRNA Profiling in Mesenchymal Stromal Cells: the Tissue Source as the Missing Piece in the Puzzle of Ageing.Stem cell reviews and reports · 2021Article
- DDR2, a discoidin domain receptor, is a marker of periosteal osteoblast and osteoblast progenitors.Journal of bone and mineral metabolism · 2020Article
- Insights into Arbutin Effects on Bone Cells: Towards the Development of Antioxidant Titanium Implants.Antioxidants (Basel, Switzerland) · 2020Article
- Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments.Journal of clinical medicine · 2020Article
- Article
- Concentrated growth factor promotes proliferation, osteogenic differentiation, and angiogenic potential of rabbit periosteum-derived cells in vitro.Journal of orthopaedic surgery and research · 2019Article
- Experimental study on healing of long bone defects treated with fibrin membrane enriched with platelet growth factors and periosteal mesenchymal stem cells in rabbit: Radiographical and histopathological evaluations.Veterinary research forum : an international quarterly journal · 2019Article
- Bone marrow cell homing to sites of acute tibial fracture:EJNMMI research · 2018Article
- Live Tissue Imaging to Elucidate Mechanical Modulation of Stem Cell Niche Quiescence.Stem cells translational medicine · 2017Article
- The effects of hypoxia and serum-free conditions on the stemness properties of human adipose-derived stem cells.Cytotechnology · 2016Article
- Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair.Frontiers in genetics · 2016Review
- Decoupling the role of stiffness from other hydroxyapatite signalling cues in periosteal derived stem cell differentiation.Scientific reports · 2015Article
- Human Periosteal Derived Stem Cell Potential: The Impact of age.Stem cell reviews and reports · 2015Article
- Stem cell origin differently affects bone tissue engineering strategies.Frontiers in physiology · 2015Article
- Periosteum derived stem cells for regenerative medicine proposals: Boosting current knowledge.World journal of stem cells · 2014Review
- Alveolar bone loss: mechanisms, potential therapeutic targets, and interventions.Advances in dental research · 2014Review
- CXCL12/CXCR4 signaling and other recruitment and homing pathways in fracture repair.BoneKEy reports · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesenchymal stem cells (MSCs) are promising tools for studying the mechanisms of development and for the regeneration of injured tissues. Correct selection of the MSCs source is crucial in order to obtain a more efficient treatment and, in this respect Periosteum-Derived Cells (PDPCs) may represent an interesting alternative to bone marrow MSCs for osteochondral tissue regeneration. In the present study we have isolated and characterized a MSCs population from the periosteum of human adult donors. PDPCs were expanded under specific culture conditions that prevent fibroblast contamination and support the maintenance of their undifferentiated phenotype. We show, for the first time, that PDPCs expresses VEGF receptor (Flt1 and KDR/Flk1) proteins and that they were similar to bone marrow Multipotent Adult Progenitor Cells (MAPCs). Since the latter are able to differentiate into endothelial cells, we tested the possible PDPCs commitment toward an endothelial phenotype in view of bone tissue engineering approaches that takes into account not only bone formation but also vascularization. PDPCs were treated with two different VEGF concentrations for 7 and 15 days and, alternatively, with the supernatant of human primary osteoblasts. Differently from MAPCs our PDPCs were unable to differentiate into endothelial cells after their in vitro VEGF treatment. On the contrary, growth factor stimulation induces PDPCs differentiation toward osteoblasts. We concluded that in PDPCs the presence of VEGF receptors is related to different cross-talk between osteogenesis and angiogenesis that could involve in situ PDPCs recruitment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.